Mandibular growth rates in human fetal development

Bareggi, Renato; Sandrucci, Maria A.; Baldini, Giovanna; Grill, Vittorio; Zweyer, Marina; Narducci, Paola

doi:10.1016/0003-9969(94)00142-x

Cited by 16 publications

(11 citation statements)

References 16 publications

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“…The fusion of the functional units of the mandible was observed by the end of the embryonic period (Przystańska et al 2007). During the 11th week, when the Meckel's cartilage becomes smaller and the secondary cartilage of the condylar process begins to set, mandibular growth proved to be a critical moment for mandibular development (Bareggi et al 1995).…”

Section: Discussionmentioning

confidence: 99%

The Meckel’s cartilage in human embryonic and early fetal periods

Wyganowska‐Świątkowska

Przystańska

2010

Anat Sci Int

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The Meckel's cartilage itself and the mandible are derived from the first branchial arch, and their development depends upon the contribution of the cranial neural crest cells. The prenatal development of the Meckel's cartilage, along with its relationship to the developing mandible and the related structures, were studied histologically in human embryos and fetuses. The material was obtained from a collection of the Department of Anatomy, and laboratory procedures were used to prepare sections, which were stained according to standard light-microscopy methods. The formation of the Meckel's cartilage and its related structures was observed and documented. Some critical moments in the development of the Meckel's cartilage are suggested. The sequential development of the Meckel's cartilage started as early as stage 13 (32 days) with the appearance of condensation of mesenchymal cells within the mandibular prominence. During stage 17 (41 days), the primary ossification center of the mandible appeared on the inferior margin of the Meckel's cartilage. The muscular attachments to the Meckel's cartilage in embryos were observed at stage 18 (44 days). Their subsequent movement into the developing mandible during the 10th week seemed to diminish the role of the Meckel's cartilage as the supportive core; simultaneously, the process of regression within the cartilage was induced. During the embryonic period, the bilateral Meckel's cartilages were in closest contact at the posterior surface of their superior margins, preceding formation of the symphyseal cartilage at this site. The event sequence in the development of the Meckel's cartilage is finally discussed.

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Section: Discussionmentioning

confidence: 99%

The Meckel’s cartilage in human embryonic and early fetal periods

Wyganowska‐Świątkowska

Przystańska

2010

Anat Sci Int

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“…14 Studying the mandible during the prenatal period is critical for the evaluation and diagnosis of congenital anomalies of the face, whereas mandibular abnormalities may be associated with several syndromes. 1,4,5,7,12 Thus, data from this study may contribute to a better understanding of the process of formation and development of the facial skeleton. 13 The purpose of this study is to provide a comparison between different anatomical dimensions of the right and left hemimandibles (HMs) during the second and early third trimester of pregnancy.…”

Section: Introductionmentioning

confidence: 87%

“…8 In some studies, researchers found variations and decreased values of the condylar angle as the gestational period evolved. 1,2,13,15 A study of the mandibular angle of 162 fetuses between 9 and 40 WPC showed that the mean values were 122±8° with no significant differences between trimesters nor between left and right HMs. 7 In another study, the observed mean of 139±1° in 36 fetuses between 13 and 37 WPC showed no significant changes in the angle during the second and third trimesters of pregnancy, comparing the right with the left HM.…”

Section: Mandibular Body X Mandibular Ramusmentioning

confidence: 99%

“…3 Research on fetal mandibular growth basically correlates the development of mandibular structures with fetus age. 1,4,5,16 In his study, Mandarim et al 6 provided a straightforward and accurate method for classifying fetal age. Once the values of certain parameters are known-such as growth of cephalic module, greater foot length, crown-rump length, and weight-it is possible to determine fetal age.…”

Section: Introductionmentioning

confidence: 99%

“…The functions exerted by the masseter and temporal muscles induce mandibular growth during the 11th week. 1 …”

Section: Introductionmentioning

confidence: 99%

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Análise do crescimento das dimensões da mandíbula em diferentes idades fetais

Mota¹,

Cardoso²,

Bechara³

et al. 2010

Dental Press J. Orthod.

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Objective: To investigate growth asymmetry between the left and right hemimandibles (HMs) during the 2nd and early 3rd trimester of pregnancy. Methods: Sixty eight hemimandibles (34 mandibles) of fetuses were used-20 female and 14 male-preserved in 10% formalin solution, and the following measurements were performed: Condyle-Coronoid Process (Co-CP), Gonion-Coronoid Process (Go-CP), Gonion-Gnathion (Go-Gn), Condyle-Gnathion (Co-Gn), Symphyseal Height (SH), Mandibular Angle (MA). The data were collected, tabulated and analyzed with the aid of SPSS software, version 11.0, 2005. One-way ANOVA test was performed to compare the mean values of anatomical measurements of the right and left HMs. Gestational ages were divided into second trimester (Period 1: 13-18 weeks and Period 2: 18-24 weeks), and early third trimester (Period 3: 24-30 weeks) of pregnancy. Results: We noted a slight growth rate asymmetry in Go-Gn, Co-CP, Co-Gn, Go-CP and SH, comparing the left and right mandibular halves, between the 2nd and early 3rd trimester of pregnancy, although not statistically significant (p > 0.05). It was also found that the mandibular angle decreased and showed a slight-though statistically significant (p < 0.05)-asymmetry in the same prenatal period. Conclusion: The authors concluded that there was a slight asymmetry in the growth rate of measurements Go-Gn, Co-CP, Co-Gn, Go-CP and SH, comparing the left with the right hemimandible between the 2nd and early 3rd trimester of gestation. AbstractKeywords: Growth. Mandible. Fetus.

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Prenatal development of the human mandible

et al. 2001

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In an effort to better understand the interrelationship of the growth and development pattern of the mandible and condyle, a sequential growth pattern of human mandibles in 38 embryos and 111 fetuses were examined by serial histological sections and soft X-ray views. The basic growth pattern of the mandibular body and condyle appeared in week 7 of fertilization. Histologically, the embryonal mandible originated from primary intramembranous ossification in the fibrous mesenchymal tissue around the Meckel cartilage. From this initial ossification, the ramifying trabecular bones developed forward, backward and upward, to form the symphysis, mandibular body, and coronoid process, respectively. We named this initial ossification site of embryonal mandible as the mandibular primary growth center (MdPGC). During week 8 of fertilization, the trabecular bone of the mandibular body grew rapidly to form muscular attachments to the masseter, temporalis, and pterygoid muscles. The mandible was then rapidly separated from the Meckel cartilage and formed a condyle blastema at the posterior end of linear mandibular trabeculae. The condyle blastema, attached to the upper part of pterygoid muscle, grew backward and upward and concurrent endochondral ossification resulted in the formation of the condyle. From week 14 of fertilization, the growth of conical structure of condyle became apparent on histological and radiological examinations. The mandibular body showed a conspicuous radiating trabecular growth pattern centered at the MdPGC, located around the apical area of deciduous first molar. The condyle growth showed characteristic conical structure and abundant hematopoietic tissue in the marrow. The growth of the proximal end of condyle was also approximated to the MdPGC on radiograms. Taken together, we hypothesized that the MdPGC has an important morphogenetic affect for the development of the human mandible, providing a growth center for the trabecular bone of mandibular body and also indicating the initial growth of endochondral ossification of the condyle.

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Mandibular growth rates in human fetal development

Cited by 16 publications

References 16 publications

The Meckel’s cartilage in human embryonic and early fetal periods

The Meckel’s cartilage in human embryonic and early fetal periods

Análise do crescimento das dimensões da mandíbula em diferentes idades fetais

Prenatal development of the human mandible

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