Mandibular bone is protected against microarchitectural alterations and bone marrow adipose conversion in ovariectomized rats

Coutel, Xavier; Delattre, Jérôme; Marchandise, Pierre; Falgayrac, Guillaume; Behal, Hélène; Kerckhofs, Greet; Penel, Guillaume; Olejnik, Cécile

doi:10.1016/j.bone.2019.06.031

Cited by 18 publications

(14 citation statements)

References 58 publications

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“…6,7 Interestingly, alveolar bone is more resistant to bone loss and adipocytes accumulation than long bone in ovariectomized rodents. 8,9 Alveolar bone contacts with the external microenvironment through the periodontal barrier, which exerts important regulatory effects on immune homeostasis of alveolar bone. 10 Although accumulating evidence demonstrated unique physiological characteristics of alveolar bone, there is a lack of systematic description of alveolar bone cell heterogeneity and the difference from long bone.…”

Section: Introductionmentioning

confidence: 99%

Mapping the immune microenvironment for mandibular alveolar bone homeostasis at single-cell resolution

Lin

Zhang

et al. 2021

Bone Res

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Alveolar bone is the thickened ridge of jaw bone that supports teeth. It is subject to constant occlusal force and pathogens invasion, and is therefore under active bone remodeling and immunomodulation. Alveolar bone holds a distinct niche from long bone considering their different developmental origin and postnatal remodeling pattern. However, a systematic explanation of alveolar bone at single-cell level is still lacking. Here, we construct a single-cell atlas of mouse mandibular alveolar bone through single-cell RNA sequencing (scRNA-seq). A more active immune microenvironment is identified in alveolar bone, with a higher proportion of mature immune cells than in long bone. Among all immune cell populations, the monocyte/macrophage subpopulation most actively interacts with mesenchymal stem cells (MSCs) subpopulation. Alveolar bone monocytes/macrophages express a higher level of Oncostatin M (Osm) compared to long bone, which promotes osteogenic differentiation and inhibits adipogenic differentiation of MSCs. In summary, our study reveals a unique immune microenvironment of alveolar bone, which may provide a more precise immune-modulatory target for therapeutic treatment of oral diseases.

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Section: Introductionmentioning

confidence: 99%

Mapping the immune microenvironment for mandibular alveolar bone homeostasis at single-cell resolution

Lin

Zhang

et al. 2021

Bone Res

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“…Interestingly, alveolar bone in the jaw is less sensitive to estrogen-deficiency-induced osteoporosis than the proximal tibia of the long bone in rats. [49][50][51][52] These data suggest that each bone exhibits the differential response to estrogen deprivation.…”

Section: Bone Remodeling In the Jawmentioning

confidence: 77%

“…It is well described that OVX surgery in animals decreases bone mass and alters the microarchitecture at various skeletal sites. Interestingly, alveolar bone in the jaw is less sensitive to estrogen‐deficiency‐induced osteoporosis than the proximal tibia of the long bone in rats 49‐52 . These data suggest that each bone exhibits the differential response to estrogen deprivation.…”

Section: Osteoclasts In the Jawbonementioning

confidence: 87%

“…For example, bone marrow stromal cells (BMSCs) derived from the jawbone exhibit higher osteogenic potential compared to those derived from other skeletal bones but less ability to differentiate into adipocytes and chondrocytes 1‐3 . Additionally, bone marrow in the jawbone exhibits a low bone marrow adipose tissue content compared to the long bone 52,64 . Furthermore, BMSCs from the jawbone display higher expression of alkaline phosphatase in response to rhBMP‐2 compared to those from long bones 65 .…”

Section: Osteoclasts In the Jawbonementioning

confidence: 99%

“…[1][2][3] Additionally, bone marrow in the jawbone exhibits a low bone marrow adipose tissue content compared to the long bone. 52,64 Furthermore, BMSCs from the jawbone display higher expression of alkaline phosphatase in response to rhBMP-2 compared to those from long bones. 65 These findings suggest that BMSCs in the jawbone are more osteogenic and more responsive to osteogenic signals than other skeletal BMSCs.…”

Section: Osteoclast Function In the Jawmentioning

confidence: 99%

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Role of osteoclasts in oral homeostasis and jawbone diseases

Omi

Mishina

2020

Oral Science International

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The jawbone is a unique structure as it serves multiple functions in mastication. Given the fact that the jawbone is remodeled faster than other skeletal bones, bone cells in the jawbone may respond differently to local and systemic cues to regulate bone remodeling and adaptation. Osteoclasts are bone cells responsible for removing old bone, playing an essential role in bone remodeling. Although bone resorption by osteoclasts is required for dental tissue development, homeostasis and repair, excessive osteoclast activity is associated with oral skeletal diseases such as periodontitis. In addition, antiresorptive medications used to prevent bone homeostasis of tumors can cause osteonecrosis of the jaws that is a major concern to the dentist. Therefore, understanding of the role of osteoclasts in oral homeostasis under physiological and pathological conditions leads to better targeted therapeutic options for skeletal diseases to maintain patients' oral health. Here, we highlight the unique features of the jawbone compared to the long bone and the involvement of osteoclasts in the jawbone-specific diseases.

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Micro-CT–Based Bone Microarchitecture Analysis of the Murine Skull

Tan

Labrinidis

Williams

et al. 2021

Methods in Molecular Biology

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X-ray micro-computed tomography (micro-CT) imaging has important applications in microarchitecture analysis of cortical and trabecular bone structure. While standardized protocols exist for micro-CT-based microarchitecture assessment of long bones, specific protocols need to be developed for different types of skull bones taking into account differences in embryogenesis, organization, development, and growth compared to the rest of the body. This chapter describes the general principles of bone microarchitecture analysis of murine craniofacial skeleton to accommodate for morphological variations in different regions of interest.

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Mandibular bone is protected against microarchitectural alterations and bone marrow adipose conversion in ovariectomized rats

Cited by 18 publications

References 58 publications

Mapping the immune microenvironment for mandibular alveolar bone homeostasis at single-cell resolution

Mapping the immune microenvironment for mandibular alveolar bone homeostasis at single-cell resolution

Role of osteoclasts in oral homeostasis and jawbone diseases

Micro-CT–Based Bone Microarchitecture Analysis of the Murine Skull

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