Mandibular bone defect healing using polylactic acid–nano-hydroxyapatite–gelatin scaffold loaded with hesperidin and dental pulp stem cells in rat

Khosronejad, Arya; Arabion, Hamidreza; Iraji, Aida; Mokhtarzadegan, Mohamad; Daneshi, Seyyed Sajad; Asadi-Yousefabad, Seyedeh-Leili; Zare, Shahrokh; Nowzari, Fariborz; Abbaspour, S.; Akbarizadeh, Fatemeh; Aliabadi, Ehsan; Amiri, Mohammad Amin; Zarei, Moein; Ebrahimi, Reyhaneh; Mussin, Nadiar M.; Kurmanalina, Madina; Tanideh, Nader; Tamadon, Amin

doi:10.1016/j.tice.2024.102700

“…In contrast, synthetic polymers such as polylactic acid (PLA), polycaprolactone (PCL), and polyethylene glycol (PEG) offer highly tunable mechanical properties, controlled degradation rates, and ease of processing [ 103 , 104 , 105 , 106 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 ]. These characteristics enable the fabrication of scaffolds that can be precisely engineered to meet the biomechanical demands of dental tissues.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, Russias et al [ 104 ] fabricated an osteoinductive PLA/hydroxyapatite composite scaffold with mechanical properties that match those of bone. More recently, Khosronejad et al [ 105 ] prepared a PLA/hydroxyapatite/gelatin/hesperidin scaffold colonized by stem cells, positively affecting bone regeneration in rats with mandibular defects. In a different study, PLA was also used as part of a triple-layered barrier membrane to prevent the unwanted process of mineralization on the membrane’s outer surface in oral environments [ 106 ].…”

Section: Polymers In Regenerative Dentistrymentioning

confidence: 99%

Polymer-Based Scaffolds as an Implantable Material in Regenerative Dentistry: A Review

Leško

¹

,

Jungová

²

,

Culenova

³

et al. 2025

JFB

1

0

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Research findings using biomineralization methods verify that Apatite layers develop on materials, which enhance their use in biomedical applications [12]. A study by Khosronejad et al [13] indicates that by increasing the HA content in PLA scaffolds, compressive strength and modulus of elasticity increase proportionally; thus, PLA scaffolds are more appropriate for load-bearing applications in bone tissue engineering. Another research investigated PLA/nano-hydroxyapatite composite 3D printing with a focus on their mechanical resistance and structural composition behavior.…”

mentioning

confidence: 95%

Optimization of Compressive Strength Properties in Fused Deposition Modeling 3D Printed PLA/HA Composites for Bone Tissue Engineering Applications

Patil

¹

,

Sathish

²

,

Othman³

et al. 2025

Engineering Reports

0

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

Biomechanics of the Temporomandibular Joint: Impact of Osteoarthritis and Advances in Improvement Strategies

Yang¹,

Chen²,

Jiang³

2025

Advances in Clinical Biomechanics [Working Title]

0

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

Mandibular bone defect healing using polylactic acid–nano-hydroxyapatite–gelatin scaffold loaded with hesperidin and dental pulp stem cells in rat

Cited by 3 publications

References 55 publications

Polymer-Based Scaffolds as an Implantable Material in Regenerative Dentistry: A Review

Polymer-Based Scaffolds as an Implantable Material in Regenerative Dentistry: A Review

Optimization of Compressive Strength Properties in Fused Deposition Modeling 3D Printed PLA/HA Composites for Bone Tissue Engineering Applications

Biomechanics of the Temporomandibular Joint: Impact of Osteoarthritis and Advances in Improvement Strategies

Contact Info

Product

Resources

About