Managing symptoms of multiple sclerosis

Schapiro, Randall T.

doi:10.1016/j.ncl.2004.09.001

Cited by 54 publications

(65 citation statements)

References 24 publications

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“…Muscle fatigue and weakness are common in these patients. 80% of patients with MS suffer from fatigue and its effects on routine affairs, and some of these patients lose their jobs because fatigue reduces the ability of individuals to perform their individual and social tasks and roles, work and activity, and maintaining a natural life and lead to posture weakness in the individual (25). In patients with MS, probably due to some factors such as muscle weakness, reduced balance, visual acuity symptoms, hearing difficulties and neurological injuries, the risk of abnormalities is increased (25).…”

Section: Discussionmentioning

confidence: 99%

“…80% of patients with MS suffer from fatigue and its effects on routine affairs, and some of these patients lose their jobs because fatigue reduces the ability of individuals to perform their individual and social tasks and roles, work and activity, and maintaining a natural life and lead to posture weakness in the individual (25). In patients with MS, probably due to some factors such as muscle weakness, reduced balance, visual acuity symptoms, hearing difficulties and neurological injuries, the risk of abnormalities is increased (25). Neurological disorders and neurological injuries are associated with reduced balance and ultimately postural weakness; inflammation of the visual nerve usually occurs in the patient MS in the form of blurred vision, pain and burning of the eyeball, and reduced of sharpness.…”

Section: Discussionmentioning

confidence: 99%

“…Symptoms of MS include fatigue, weakness, visual acuity, neurological damage and ataxia (25). It is believed that sensory systems such as vision have an important role in controlling human movement, therefore, visual impairment can lead to problems with balance, posture, and coordination (4).…”

Section: Discussionmentioning

confidence: 99%

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Spinal Cord Analysis in People with Multiple Sclerosis

Meymand

Daneshmandi

Al-Zamani

et al. 2018

Ann. Appl. Sport Sci

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Background. Multiple Sclerosis (MS) is an autoimmune, inflammatory, and chronic disease which, under the effect of the wastes of myelin degradation occurs in the white matter of the brain, spinal cord, and visual nerves. The main complications of this disease are fatigue, muscle cramps, tremor, imbalance, and walking imbalance. Objectives. The purpose of this study is to investigate the spine orientation in people with multiple sclerosis. Methods. The statistical population of this study included all patients with MS in Kerman province and the sample of this study includes 30 patients with mild MS (mean age of 33.83±8.72 years, mean height of 159.77±4.54 cm, mean weight of 63.1±11.16 kg) and 30 healthy subjects (mean age of 31.07±8.84 years, mean height of 162.58±6.61 cm, mean weight of 61.43±11.3 kg), targeted randomly selected as the subjects. First, the patients were examined by a neurologist and the EDSS of each subject was evaluated. Then their demographic data including age, height, and weight were collected. For evaluation of spinal abnormalities including torticollis and forward head, shooting method with the use of -Power shot A1200 HD Canon camera, with 0.73 validity was used; and kyphosis and lordosis abnormalities were measured using a flexible ruler, the validity of the device in comparison with the radiography technique was reported by Thylatson and Borton (1991) as 93%. In research, Hart & Rose (1986) and Lowell et al. (1989) stated the reliability of this device as 97% and 84%, respectively, and scoliometer was used for scoliosis abnormalities. The validity of this device was reported by Guillemhem et al. as 0.87. Results. The results showed that there was a significant relationship between forward head, torticollis, and lordosis abnormalities in patients with mild MS and healthy subjects (p˂0.05), while there is significant relationship between kyphosis and scoliosis (p˂0.05). Conclusion. Regarding factors such as fatigue, muscle cramping, tremor, walking abnormalities in people with multiple sclerosis and observation of some spinal abnormalities in these individuals, the implementation of corrective exercises and programs to correct postures, in them, seems necessary.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Spinal Cord Analysis in People with Multiple Sclerosis

Meymand

Daneshmandi

Al-Zamani

et al. 2018

Ann. Appl. Sport Sci

View full text Add to dashboard Cite

show abstract

“…As already noted, until relatively recently, patients with MS were encouraged not to exercise strenuously due to concerns that it might induce fatigue, overheating, and ultimately provoke an exacerbation of the disease itself [42]. Now, it is becoming more widely recognized that endurance exercise or resistance training is beneficial for those living with MS [43] and physical activity is frequently prescribed for the management of MS symptoms [44]. As physical activity can both improve vascular function [20] and antioxidant capacity [45], it is likely that the relatively active lifestyle of the current MS patients played a role in their apparently normal level of oxidative stress and vascular function.…”

Section: Oxidative Stress Vascular Function and Msmentioning

confidence: 99%

Vascular function and multiple sclerosis

et al. 2011

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Multiple sclerosis (MS) is a debilitating disease with an assumed autoimmune etiology which may lead to elevated oxidative stress, vascular dysfunction, and subsequent predisposition to cardiovascular disease. Therefore, the primary aim of this study was to evaluate vascular function and the potential role of oxidative stress in patients diagnosed with MS compared to healthy controls (C). Fourteen patients with relapsing-remitting MS (47 ± 3 years) and 13 age- and activity-matched controls (44 ± 5 years) underwent brachial artery flow-mediated dilation (FMD) and reactive hyperemia testing using ultrasound Doppler. Venous blood was analyzed for C-reactive protein (CRP), lipid hydroperoxides (LH), the ferric reducing ability of plasma (FRAP), superoxide dismutase (SOD), and catalase activity. CRP [1.8 ± 0.5 mg/L (MS), 1.0 ± 0.5 mg/L (C)] and LH [1.2 ± 0.2 μmol/L (MS), 1.1 ± 0.1 μmol/L (C)] were not different between MS patients and controls. FMD [8.0 ± 1.2% (MS) and 9.2 ± 1.6% (C)] and reactive hyperemia [380 ± 61 mL (MS) and 402 ± 69 mL (C)] were also not different between groups. Vascular function, as assessed by both FMD and reactive hyperemia, was not impaired in patients with MS compared to controls. Further, there was no evidence of elevated systemic inflammation or oxidative stress in these patients, who were currently all in remission. These findings suggest that impaired vascular function, elevated inflammation and oxidative stress are not an obligatory accompaniment to MS.

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“…Chemical denervation using botulinum toxin has revolutionized treatment for many disorders involving excessive muscle activity (7), including movement disorders such as cervical dystonia (8,9), tremor (10,11), cerebral palsy (12)(13)(14), limb spasticity following stroke (15,16), or multiple sclerosis (17)(18)(19). Botulinum toxin injections have also been reported to be beneficial in bringing about pain relief in a variety of conditions, including low back pain (20)(21)(22)(23)(24).…”

Section: Botulinum Toxin Type a For Chronic Low Back Pain For Healthmentioning

confidence: 99%