Managing Specialty Medication Services Through a Specialty Pharmacy Program: The Case of Oral Renal Transplant Immunosuppressant Medications

Tschida, Suzanne J.; Aslam, Saad; Khan, Tanvir T.; Sahli, Brett; Shrank, William H.; Lal, Lincy S.

doi:10.18553/jmcp.2013.19.1.26

Cited by 30 publications

(34 citation statements)

References 34 publications

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“…Furthermore, IMS claims data may not reliably describe prescribing practices in this population from the pre‐operative setting after listing for transplant through the immediate postoperative period, as medication changes may not be captured in a timely manner. As the patients included in this analysis may have been excluded from the registry study and as renal transplant recipients have shown better rates of compliance in specialty pharmacies, our study is pertinent to show that the disadvantages of PI‐based regimens may not confer across all populations …”

Section: Discussioncontrasting

confidence: 99%

Impact of antiretroviral regimen on renal transplant outcomes in HIV‐infected recipients

Sparkes

Manitpisitkul

Masters

et al. 2018

Transplant Infectious Dis

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Section: Discussioncontrasting

confidence: 99%

Impact of antiretroviral regimen on renal transplant outcomes in HIV‐infected recipients

Sparkes

Manitpisitkul

Masters

et al. 2018

Transplant Infectious Dis

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“…First, patients picking up their medication from a pharmacy might receive extra adherence‐enhancing interventions compared to those receiving them at the physician's office. Pharmacies are increasingly augmenting their services with adherence support, an intervention proven effective in kidney transplant patients 52, 53. Alternatively, receiving medication at a physician's office, which allows especially close follow‐up, might reflect the physician's perception of a higher nonadherence risk.…”

Section: Discussionmentioning

confidence: 99%

Multilevel factors are associated with immunosuppressant nonadherence in heart transplant recipients: The international BRIGHT study

Denhaerynck

Berben

Dobbels

et al. 2018

American Journal of Transplantation

100

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Factors at the level of family/healthcare worker, organization, and system are neglected in medication nonadherence research in heart transplantation (HTx). The 4‐continent, 11‐country cross‐sectional Building Research Initiative Group: Chronic Illness Management and Adherence in Transplantation (BRIGHT) study used multistaged sampling to examine 36 HTx centers, including 36 HTx directors, 100 clinicians, and 1397 patients. Nonadherence to immunosuppressants—defined as any deviation in taking or timing adherence and/or dose reduction—was assessed using the Basel Assessment of Adherence to Immunosuppressive Medications Scale© (BAASIS ©) interview. Guided by the Integrative Model of Behavioral Prediction and Bronfenbrenner's ecological model, we analyzed factors at these multiple levels using sequential logistic regression analysis (6 blocks). The nonadherence prevalence was 34.1%. Six multilevel factors were associated independently (either positively or negatively) with nonadherence: patient level: barriers to taking immunosuppressants (odds ratio [OR]: 11.48); smoking (OR: 2.19); family/healthcare provider level: frequency of having someone to help patients read health‐related materials (OR: 0.85); organization level: clinicians reporting nonadherent patients were targeted with adherence interventions (OR: 0.66); pickup of medications at physician's office (OR: 2.31); and policy level: monthly out‐of‐pocket costs for medication (OR: 1.16). Factors associated with nonadherence are evident at multiple levels. Improving medication nonadherence requires addressing not only the patient, but also family/healthcare provider, organization, and policy levels.

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“…For example, the Patient Activation Measures23 and other self-report scales rely on direct assessment and results can be unpredictable due to human variability 24. As observed in their use with MTM, the quality of the data obtained is highly dependent upon the practitioner–patient relationship 25. The concordance of these types of measures with actual adherence behavior varies widely based on the skill of the practitioner 26–28.…”

Section: Matching the Hammer To The Nail – Purposeful Measurementmentioning

confidence: 99%

Coming full circle in the measurement of medication adherence: opportunities and implications for health care

Buono¹,

Vrijens²,

Bosworth³

et al. 2017

PPA

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There is little debate that medication nonadherence is a major public health issue and that measuring nonadherence is a crucial step toward improving it. Moreover, while measuring adherence is becoming both more feasible and more common in the era of electronic information, the reliability and usefulness of various measurements of adherence have not been well established. This paper outlines the most commonly used measures of adherence and discusses the advantages and disadvantages of each that depend on the purpose for which the measure will be used. International consensus statements on definitions and guidelines for selection and use of medication adherence measures were reviewed. The quality of recommended measures was evaluated in selected publications from 2009 to 2014. The most robust medication adherence measures are often ill suited for large-scale use. Less robust measures were found to be commonly misapplied and subsequently misinterpreted in population-level analyses. Adherence assessment and measurement were rarely integrated into standard patient care practice patterns. Successful scalable and impactful strategies to improve medication adherence will depend on understanding how to efficiently and effectively measure adherence.

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Managing Specialty Medication Services Through a Specialty Pharmacy Program: The Case of Oral Renal Transplant Immunosuppressant Medications

Cited by 30 publications

References 34 publications

Impact of antiretroviral regimen on renal transplant outcomes in HIV‐infected recipients

Impact of antiretroviral regimen on renal transplant outcomes in HIV‐infected recipients

Multilevel factors are associated with immunosuppressant nonadherence in heart transplant recipients: The international BRIGHT study

Coming full circle in the measurement of medication adherence: opportunities and implications for health care

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