Managing Recurrent Vulvovaginal Candidiasis: Intermittent Prevention with Itraconazole

Itraconazole in the treatment of acute and recurrent vulvovaginal candidosis: comparison of a 1‐day and a 3‐day regimen

“…Severe episodes of acute vaginitis and individual attacks of recurrent VVC should be treated with long‐course antifungal drug regimens to achieve higher cure rates or drop in frequency of relapses. Alternatively, the application of a suppressive treatment of 200 mg itraconazole once monthly for 6 months in RVVC patients about the first day of menstrual cycle was found to be useful 30–32 . Owing to the chronic nature of RVVC and the difficulty of mycological eradication, prolonged and prophylactic therapeutic regimens are preferred.…”

“…Alternatively, the application of a suppressive treatment of 200 mg itraconazole once monthly for 6 months in RVVC patients about the first day of menstrual cycle was found to be useful. [30][31][32] Owing to the chronic nature of RVVC and the difficulty of mycological eradication, prolonged and prophylactic therapeutic regimens are preferred. Success of the therapy is dependent on elimination of true causes of RVVC by understanding the underlying mechanisms of this disease.…”

Recurrent vulvovaginal candidiasis

“…The later status can almost always be achieved by long term maintenance suppressive regimens of antifungal drugs. (11)(12)(13)(45)(46)(47) Accordingly, once the diagnosis of RVVC is confirmed, accompanied by microbiologic confirmation of an azole sensitive strain of Candida, but not C.glabrata or C.krusei, attempts should be made at identifying triggering or precipitating stimuli. Apart from antibiotics, other risk factors rarely emerge, but M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 9 may include lowering intake of sugar or discontinuing oral contraceptives, although data to support these actions are anectdotal and proof of efficacy minimal.…”

Possible Treatment Options for Recurrent Yeast Vaginal Yeast Infections

“…Most studies recommend prophylactic duration for 6 months and then reevaluation. However, there is evidence that a longer prophylactic period is needed and treatment is not a permanent solution because many women experience recurrences once prophylaxis is discontinued [9][10][11][12].…”