Managing Patients with Cutaneous B-Cell and T-Cell Lymphomas Other Than Mycosis Fungoides

Kheterpal, Meenal; Mehta‐Shah, Neha; Virmani, Pooja; Myskowski, Patricia L.; Moskowitz, Alison J.; Horwitz, Steven M.

doi:10.1007/s11899-016-0322-5

Cited by 7 publications

(4 citation statements)

References 106 publications

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“…Cutaneous lymphomas (CL) are a heterogeneous group of lymphomas that present in the skin. The two main types of CLs are cutaneous T-cell lymphomas (CTCL) and cutaneous B-cell lymphomas (116). CTCL is much more common than cutaneous B-cell lymphomas, with Mycosis Fungoides (MF) and Sezary (117).…”

Section: Cutaneous Lymphomamentioning

confidence: 99%

Next-generation sequencing in dermatology

King,

Deirawan,

Klein

et al. 2023

Front. Med.

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Over the past decade, Next-Generation Sequencing (NGS) has advanced our understanding, diagnosis, and management of several areas within dermatology. NGS has emerged as a powerful tool for diagnosing genetic diseases of the skin, improving upon traditional PCR-based techniques limited by significant genetic heterogeneity associated with these disorders. Epidermolysis bullosa and ichthyosis are two of the most extensively studied genetic diseases of the skin, with a well-characterized spectrum of genetic changes occurring in these conditions. NGS has also played a critical role in expanding the mutational landscape of cutaneous squamous cell carcinoma, enhancing our understanding of its molecular pathogenesis. Similarly, genetic testing has greatly benefited melanoma diagnosis and treatment, primarily due to the high prevalence of BRAF hot spot mutations and other well-characterized genetic alterations. Additionally, NGS provides a valuable tool for measuring tumor mutational burden, which can aid in management of melanoma. Lastly, NGS demonstrates promise in improving the sensitivity of diagnosing cutaneous T-cell lymphoma. This article provides a comprehensive summary of NGS applications in the diagnosis and management of genodermatoses, cutaneous squamous cell carcinoma, melanoma, and cutaneous T-cell lymphoma, highlighting the impact of NGS on the field of dermatology.

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Section: Cutaneous Lymphomamentioning

confidence: 99%

Next-generation sequencing in dermatology

King,

Deirawan,

Klein

et al. 2023

Front. Med.

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“…Table 1: Recommendations for the treatment of primary cutaneous follicle center lymphoma [18] CBCL Primary cutaneous marginal zone lymphoma [19] Radiation therapy (RT), curative surgery, and sometimes antibiotics are all viable options for patients with localized or locally-confined disease. Those with PCMZL may experience higher relapse rates after targeted treatment than those with PCFCL.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…Table 2: Recommendations for the treatment of primary cutaneous marginal zone lymphoma [19] CBCL Primary cutaneous diffuse large B-cell lymphoma, legtype [20] Relapses in the skin are common, and PCDLBCL-LT often spreads quickly. First-line therapy for isolated, regional, or systemic illness is radiotherapy (RT) alone or in conjunction with R-CHOP.…”

Section: Clinical Featuresmentioning

confidence: 99%

Prevalence of cutaneous T and B cell lymphoma

Badawy¹,

Hassan²,

Atlam³

et al. 2023

Int. J. Dermatol. Venereology Leprosy Sci.

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Differentiating primary cutaneous lymphoma from secondary cutaneous lymphoma is crucial since the former develops first in the skin without any systemic involvement. Because of the clinical and histological similarities between primary and secondary cutaneous lymphomas, distinguishing between the two can be difficult. In order to prevent any diagnostic issues, it may be necessary to do thorough staging investigations. PCTCL is more prevalent than PCBCL since seventy-one percent of cases are PCTCL (7.7 cases/million inhabitants/year), while 29 percent of cases are PCBCL (3.1 cases/million inhabitants/year), according to an American epidemiological study published in 2009; More males than females are affected by PCL, with a male-to-female ratio of 1.72 (14.0 vs. 8.2 cases/million inhabitants/year). Also, the rate is highest among blacks, lowest among Hispanic Caucasians, and intermediate among Asians, with an annual rate of 11.5, 7.9, and 7.1 cases per million people. Blacks had a higher incidence of PCTCL (10.0 cases/million inhabitants/year) while non-Hispanic Caucasians had a higher incidence of PCBCL (3.5 cases/million inhabitants/year). Incidence of PCL was higher in 2001-2003 (14.3 vs. 5.0 cases/million inhabitants/year) and stabilized in 2004-2005 (12.7 vs. 5.0 cases/million inhabitants/year) according to this study.

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“…Treatment of Cancer and International Society for Cutaneous Lymphoma do not mention intralesional corticosteroids in the treatment of PCMZL, even though there have been a few reports, including ours, of successful treatment with intralesional steroids. 5,9,10,11 We propose that close monitoring with intralesional steroid injection of new lesions may be an effective and well-tolerated way to treat chronic PCMZL, and that larger controlled trials of this therapy should be encouraged.…”

Section: Current Management Guidelines By the European Organization Fmentioning

confidence: 99%

Intralesional Corticosteroids for Long-term Control of Primary Cutaneous Marginal Zone Lymphoma without systemic involvement

Tiwari¹,

Hall²,

Rajpara³

et al. 2019

Marshall Journal of Medicine

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Primary cutaneous marginal zone lymphoma (PCMZL) is a B cell lymphoma with a very low metastatic rate. Radiographic monitoring for internal involvement may be indicated initially. Favored treatments include radiation and excision. Radiation has high risk of local recurrence. Excision carries risk of infection and scarring. We report successful long-term treatment of recurrent PCMZL via intralesional steroid injections into new lesions as they arose. This was preferred by the patient over her prior radiation and surgical treatments. Intralesional steroids have the advantages of being simple and well tolerated, without exposure to ionizing radiation or to the infection and scarring associated with surgery.

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Managing Patients with Cutaneous B-Cell and T-Cell Lymphomas Other Than Mycosis Fungoides

Cited by 7 publications

References 106 publications

Next-generation sequencing in dermatology

Next-generation sequencing in dermatology

Prevalence of cutaneous T and B cell lymphoma

Intralesional Corticosteroids for Long-term Control of Primary Cutaneous Marginal Zone Lymphoma without systemic involvement

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