Background: An important issue of environmental protection process is the solid waste management that includes responsible planning of collecting, transporting, processing and disposing of hazardous and non-hazardous solid waste material. The health of public, patients and professionals alike are affected by poor waste management practices. The study highlights a holistic approach of biomedical waste management with regards to the chain of environmental and health risks and concerns aimed in achieving the fundamental premises for a systemic approach of biomedical waste management. An attempt has been made to critically review the current management practices adopted in V.S.S. Medical college & Hospital. Following the Rules and Regulation the methods for segregation, packaging, labeling and the treatment techniques for reduction in volume, neutralization and final disposal of the biomedical waste are analysed. Methods: Personal observations of the waste treatment and disposal practices and Assessment of knowledge, attitude and practices of working personnel with the help of questionnaires were followed in this study. The information obtained has been confirmed by means of direct spot visit. The views and suggestions of working personnel over existing conditions/methods of biomedical waste management in the hospitals were also recorded. The information obtained was later confirmed by means of direct observations. Results:There are 20 units having total bed capacity of 1006. The daily generation of category 1 & 2 is 40-50 kg/day. The daily generation of category 3 waste is 2-3 kg which was measured one day after one day. Category 4&5 waste generation amounting 30-40 Kg/ day. The Solid waste, (category 6) generation amounting 80-90kg/ day. The solid waste, category 7 waste generation is 30-40 kg/ day. Waste generated from laboratory (category,8) was estimated and found to be 30-40 litres/ day and the incineration ash category 9 generation was recorded as 3-4 Kg/ day. The chemical waste category 10 was not properly assessed by the CBWTF.The current segregation practice is not that efficient in reducing the waste going to incinerator. According to the opinion of employees at V.S.S.Medical College and hospital burla, the important reasons for the improper segregation of wastes are; inappropriate location of waste bins, waste bins being full and lack of knowledge regarding the constituents of medical waste. Conclusion: The performance of CBWTF can be enhanced with cooperative efforts of BMW generators possible if a healthy coordination exists between CBWTF and BMW generators.