Managing Intractable Symptoms of Parkinson's Disease: A Nonsurgical Approach Employing Infralow Frequency Neuromodulation

Legarda, Stella B.; Michas-Martin, P Andreas; McDermott, Dana

doi:10.3389/fnhum.2022.894781

Cited by 1 publication

(1 citation statement)

References 57 publications

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“…Dysphonia, dysphagia, and emotionless facial expressions are also clinical features. Recent research has linked the pathogenic mechanism 10.3389/fnut.2023.1121789 of PD to the degeneration of dopaminergic neurons as well as dysfunctions of astrocytes and microglia (6,7). Nevertheless, the mechanism of PD's pathogenesis is still only partially understood.…”

Section: Introductionmentioning

confidence: 99%

Dietary supplementation of Acanthopanax senticosus extract alleviates motor deficits in MPTP-induced Parkinson’s disease mice and its underlying mechanism

Jia

et al. 2023

Front. Nutr.

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Acanthopanax senticosus extract (ASE), a dietary supplement with antifatigue, neuroprotective, and immunomodulatory properties, has been widely used due to its high polyphenol content. Our previous study showed that ASE could be used to treat Parkinson’s disease (PD) as it contains multiple monoamine oxidase B inhibitors prescribed in early PD. However, its mechanism remains ambiguous. In this study, we investigated the protective effects of ASE on MPTP-induced PD in mice and explored the underlying mechanisms of action. We found that the administration of ASE significantly improved motor coordination in mice with MPTP-induced PD. As shown by quantitative proteomic analysis, 128 proteins’ expression significantly changed in response to ASE administration, most of which were involved with Fcγ receptor-mediated phagocytosis in macrophages and monocytes signaling pathway, PI3K/AKT signaling pathway, and insulin receptor signaling pathway. Furthermore, the network analysis results showed that ASE modulates protein networks involved in regulating cellular assembly, lipid metabolism, and morphogenesis, all of which have implications for treating PD. Overall, ASE served as a potential therapeutic because it regulated multiple targets to improve motor deficits, which could lay the strong foundation for developing anti-PD dietary supplements.

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Section: Introductionmentioning

confidence: 99%

Dietary supplementation of Acanthopanax senticosus extract alleviates motor deficits in MPTP-induced Parkinson’s disease mice and its underlying mechanism

Jia

et al. 2023

Front. Nutr.

View full text Add to dashboard Cite

show abstract

Managing Intractable Symptoms of Parkinson's Disease: A Nonsurgical Approach Employing Infralow Frequency Neuromodulation

Cited by 1 publication

References 57 publications

Dietary supplementation of Acanthopanax senticosus extract alleviates motor deficits in MPTP-induced Parkinson’s disease mice and its underlying mechanism

Dietary supplementation of Acanthopanax senticosus extract alleviates motor deficits in MPTP-induced Parkinson’s disease mice and its underlying mechanism

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