Managing delayed-onset muscle soreness: Lack of effect of selected oral systemic analgesics

“…This is surprising, since such models mimic clinical inflammatory muscle pain, which is treated successfully with acetylsalicylic acid [16,31,39]. For the cold pressor test different results were seen for NSAIDs and paracetamol.…”

Section: Mechanistic Aspectsmentioning

confidence: 99%

Assessing efficacy of non‐opioid analgesics in experimental pain models in healthy volunteers: an updated review

Staahl

Olesen

Arendt‐Nielsen

et al. 2009

Brit J Clinical Pharma

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AIMExperimental pain models may help to evaluate the mechanisms of analgesics and target the clinical indications for their use. This review, the second in a series of two, addresses how the efficacy of non-opioid analgesics have been assessed in human volunteers using experimental pain models. METHODSA literature search was completed for randomized controlled studies that included human experimental pain models, healthy volunteers and non-opioid analgesics. RESULTSNonsteroidal anti-inflammatory drugs worked against various types of acute pain as well as in hyperalgesia. Analgesia from paracetamol was difficult to detect in experimental pain and the pain needed to be assessed with very sensitive methods like evoked brain potentials. The N-methyl-D-aspartate antagonists exemplified by ketamine generally needed strong, long-lasting or repeated pain in the skin for detectable analgesia, whereas pain in muscle and viscera generally was more easily attenuated. Gabapentin worked well in several models, particularly those inducing hyperalgesia, whereas lamotrigine was weak in modulation of experimental pain. Imipramine attenuated pain in most experimental models, whereas amitriptyline had weaker effects. Delta-9-tetrahydrocannabinol attenuated pain in only a few models.

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“…10 Antioksidan ilavenin eksantrik egzersiz sonrasında el bileği fleksörlerinde oluşan kas ağrısına etkisinin olmadığı belirtilmiştir. 77 E ve C vitamini ilavesi alan grupta eksantrik egzersizden sonraki bir ve ikinci günde performansta meydana gelen düşüşün daha az olduğu, ancak GKA düzeylerinin benzer olduğu kaydedilmiştir. 78 Benzer şekilde Theodorou ve ark., E ve C vitamini takviyesinin kas hasarı, performans ve oksidatif strese etkisinin olmadı-ğını belirtmişlerdir.…”

Section: Geci̇kmi̇ş Kas Ağrisi Ve Anti̇oksi̇dan Kullanimiunclassified

Delayed Onset Muscle Soreness and Mechanisms: Relation with Oxidative Stress: Review

Dokumacı¹,

Atabek²

2016

Turkiye Klinikleri J Sports Sci

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Managing delayed-onset muscle soreness: Lack of effect of selected oral systemic analgesics

Cited by 56 publications

References 24 publications

Human Experimental Pain Models for Assessing the Therapeutic Efficacy of Analgesic Drugs

Human Experimental Pain Models for Assessing the Therapeutic Efficacy of Analgesic Drugs

Assessing efficacy of non‐opioid analgesics in experimental pain models in healthy volunteers: an updated review

Delayed Onset Muscle Soreness and Mechanisms: Relation with Oxidative Stress: Review

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