Managing COVID-19-Positive Maternal–Infant Dyads: An Italian Experience

Salvatori, Guglielmo; Rose, Domenico Umberto De; Concato, Carlo; Alario, Dario; Olivini, Nicole; Dotta, Andrea; Campaña, Andrea

doi:10.1089/bfm.2020.0095

Cited by 80 publications

(90 citation statements)

References 3 publications

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“…11 However, the currently available evidence does not support the latter indication. Indeed, no data demonstrated the presence of SARS-CoV-2 virus in breastmilk 5,26,28 ; in contrast, antibodies to SARS-CoV-2 have been detected in breastmilk in anecdotal reports.…”

Section: Discussionmentioning

confidence: 96%

“…One of the two newborns was completely asymptomatic, while the other showed mild symptoms (cough, diarrhea, and poor feeding) with no need for intensive care. 28 The risk of horizontal transmission could probably be reduced by the adoption of strict hygiene measures during skin to skin or breastfeeding. Indeed, the majority of the reviewed guidelines (7 out of 11) 12-15,22-24 endorses the practice of in-hospital rooming-in for the infected mother and the healthy newborn under strict hygiene measures, while the AAP guidelines and Chinese Consensus recommend separation of the dyad, 11,16,17 and the CDC having a prudent approach by assessing separation or rooming-in on a case-by-case basis.…”

Section: Discussionmentioning

confidence: 99%

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Management and Nutrition of Neonates during the COVID-19 Pandemic: A Review of the Existing Guidelines and Recommendations

Genoni¹,

Conio²,

Binotti³

et al. 2020

Am J Perinatol

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Objective We aimed at reviewing the currently available guidelines and scientific recommendations regarding the neonatal in-hospital management and feeding in the light of the coronavirus disease 2019 (COVID-19) pandemic. Study Design We systematically searched the guideline databases, Medline, Embase, and nationale/international neonatal societies websites as of June 19, 2020, for guidelines on neonatal management and feeding during the COVID-19 pandemic, at the same time assessing the methodological quality using the Appraisal of Guidelines for Research and Evaluation II tool. Results Eleven guidelines were included. The Chinese and American recommendations suggest separation of the mother and her neonate, whereas in French, Italian, UK, Canadian, and World Health Organization consensus documents the rooming-in is suggested, with Centers for Disease Control and Prevention guidelines suggesting to decide on a case-by-case basis. All the guidelines recommend breastfeeding or feeding with expressed maternal milk; the only exception is the Chinese recommendations, these last suggesting to avoid breastfeeding. Conclusion This review may provide a useful tool for clinicians and organizers, highlighting differences and similarities of the existing guidelines on the management and feeding strategies in the light of the COVID-19 pandemic. Key Points

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Management and Nutrition of Neonates during the COVID-19 Pandemic: A Review of the Existing Guidelines and Recommendations

Genoni¹,

Conio²,

Binotti³

et al. 2020

Am J Perinatol

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show abstract

“…None of these evidences has been demonstrated so far. SARS-CoV-2 virus has not been detected in human milk samples in most reports-thus excluding the transmission by this route 23,24 -with the exception of scattered reports describing SARS-CoV-2 RNA detection in maternal milk samples. 6,[25][26][27] Notably, the same authors stated that the risk of the milk contamination by maternal respiratory secretions could not be ruled out.…”

Section: Breastfeedingmentioning

confidence: 95%

Vertical Transmission of SARS-CoV-2 (COVID-19): Are Hypotheses More than Evidences?

et al. 2020

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In spite of the increasing, accumulating knowledge on the novel pandemic coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), questions on the coronavirus disease-2019 (COVID-19) infection transmission from mothers to fetuses or neonates during pregnancy and peripartum period remain pending and have not been addressed so far. SARS-CoV-2, a RNA single-stranded virus, has been detected in the amniotic fluid, in the cord blood and in the placentas of the infected women. In the light of these findings, the theoretical risk of intrauterine infection for fetuses, or of peripartum infection occurring during delivery for neonates, has a biological plausibility. The extent of this putative risk might, however, vary during the different stages of pregnancy, owing to several variables (physiological modifications of the placenta, virus receptors' expression, or delivery route). This brief review provides an overview of the current evidence in this area. Further data, based on national and international multicenter registries, are needed not only to clearly assess the extent of the risk for vertical transmission, but also to ultimately establish solid guidelines and consistent recommendations. Key Points

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“… 12 However, due to the outrageous number of infected children, some fatal cases are being reported, associated with extrapulmonary complications, pointing to a need of medical and scientific attention. 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 …”

Section: Introductionmentioning

confidence: 99%

Extrapulmonary manifestations of COVID-19 in children: a comprehensive review and pathophysiological considerations

Pousa¹,

Mendonça²,

Oliveira³

et al. 2021

Jornal de Pediatria

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Objective The aim of this review was to summarize the most common extrapulmonary manifestations in pediatric patients with COVID-19, as well as to discuss clinical, epidemiological, and pathophysiological aspects of these clinical presentations in children. Source of data An extensive search of literature was performed in order to identify pediatric cases with extrapulmonary manifestations between January 1, 2020 and June 21, 2020. Generic keywords, such as “Novel coronavirus” or “Novel coronavirus 2019” or “2019 nCoV” or “COVID-19” or “SARS-CoV-2” were searched on PubMed database, associated either with age filters or generic pediatric terms. Summary of findings A total of 28 articles, including 199 patients, were considered suitable to review and data extraction. The main findings were summarized in tables. The main non-pulmonary manifestations in pediatric patients, in decreasing order of frequency, were gastrointestinal, renal, cardiovascular, neurological, hematological and lymphatic, cutaneous, hepatic, ocular, olfactory, and gustatory. Multisystem impairment and Kawasaki-like disease were also described. Conclusions Differences in immune response of children and variations of tissue expression of angiotensin converting enzyme 2, the virus receptor, are likely to influence clinical, epidemiological, and pathophysiological patterns of the disease.

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Managing COVID-19-Positive Maternal–Infant Dyads: An Italian Experience

Cited by 80 publications

References 3 publications

Management and Nutrition of Neonates during the COVID-19 Pandemic: A Review of the Existing Guidelines and Recommendations

Management and Nutrition of Neonates during the COVID-19 Pandemic: A Review of the Existing Guidelines and Recommendations

Vertical Transmission of SARS-CoV-2 (COVID-19): Are Hypotheses More than Evidences?

Extrapulmonary manifestations of COVID-19 in children: a comprehensive review and pathophysiological considerations

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