Managing CAP in the ICU

Liapikou, Adamantia; Makrodimitri, Sotiria; Myrsini, Melaxroinidou; Toumbis, Michael

doi:10.1007/s11908-015-0504-7

Cited by 3 publications

(1 citation statement)

References 43 publications

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“…CAP disproportionately affects persons who are very young or very old, with an annual incidence of 9.2 to 33 per 1000 person-years [ 1 , 2 ]. Out of an estimated 878,000 adults 45 years and older who were hospitalized with a primary diagnosis of CAP in 2010, 71% were 65 years or older, and 10% to 20% required admission to the intensive care unit (ICU) [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Biomarker Value in the Diagnosis of Community-Acquired Pneumonia with Concomitant Chronic Heart Failure

Rachina

Бобылев

Лазарев³

et al. 2021

JCM

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The diagnosis of community-acquired pneumonia (CAP) with chronic heart failure (CHF) is associated with objective difficulties. Our case–control study aims to establish whether established serum inflammatory biomarkers are relevant to the diagnosis of CAP in patients with CHF. Seventy inpatients with previously diagnosed CHF and suspected non-severe CAP were recruited and then stratified into two subgroups with confirmed and rejected diagnosis of CAP. С-reactive protein (CRP), procalcitonin (PCT), tumor necrosis factor α (TNFα), interleukin-6 (IL-6) and brain natriuretic peptide (BNP) were measured. The value of biomarkers was determined using logistic regression, and their discriminatory efficacy was assessed by analyzing receiver operating characteristic (ROC) curves. Significantly higher levels of CRP 50.0 (35.5–98.5) mg/L, PCT 0.10 (0.05–0.54) ng/mL and IL-6 46.1(21.4–150.3) pg/mL in cases were identified as compared to the control group—15.0 (9.5–25.0) mg/L, 0.05 (0.05–0.05) ng/mL and 13.6 (9.5; 25.0) pg/mL, respectively. The Area Under the ROC Curve (95% CI) was the highest for CRP—0.91 (0.83–0.98), followed by PCT—0.81 (0.72–0.90) and IL-6—0.81 (0.71–0.91). A CRP value of >28.5 mg/L had an optimal sensitivity and specificity ratio (85.7/91.4%). In conclusion, the measurement of serum CRP, PCT and IL-6 levels can be useful for the diagnosis of CAP in patients with CHF. CRP showed optimal diagnostic utility in this population.

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Section: Introductionmentioning

confidence: 99%

Biomarker Value in the Diagnosis of Community-Acquired Pneumonia with Concomitant Chronic Heart Failure

Rachina

Бобылев

Лазарев³

et al. 2021

JCM

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Measuring the intensive care experience of intensive care unit patients: A cross-sectional study in western China

Hu,

Wang,

Zhou

et al. 2024

Australian Critical Care

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Infecciones en el paciente crítico

Martín

Bernal

Teruel

et al. 2018

Medicine - Programa de Formación Médica Continuada Acreditado

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ResumenIntroducción. Las infecciones son muy frecuentes en los pacientes que se encuentran ingresados en los servicios de medicina intensiva, siendo unas veces motivo de ingreso y en otras la infección se adquiere durante el ingreso.Epidemiologia. Las causas más frecuentes de infección adquirida en la comunidad que precisa ingreso en la UCI son las infecciones respiratorias, infecciones urinarias y las infecciones del sistema nervioso central. Dentro de las infecciones adquiridas en la UCI, las asociadas a dispositivos son las más frecuentes. Etiología. Los gérmenes más frecuentes en la UCI son los Gram negativos.Etiopatogenia. En el paciente crítico se aúnan factores, haciéndolos especialmente vulnerables a las infecciones.Manifestaciones clínicas. Dependerán de la localización de la infección.Diagnóstico. Debe ser precoz dada su alta mortalidad.Pronóstico. Las infecciones nosocomiales se asocian con un aumento de la mortalidad y la estancia.Tratamiento. El retraso en el tratamiento se asocia con un aumento de la mortalidad. Abstract Infections in critically ill patientsIntroduction. Infections are very frequent in patients who are admitted to Intensive Care Units, sometimes being a reason for admission and in others the infection is acquired during ICU stay.Epidemiology. The most frequent causes of acquired infection in the community that require admission to the ICU are respiratory infections, urinary tract infections and infections of the central nervous system. Among the infections acquired in the ICU, devices-associated infections are the most frequent.Etiology. The most frequent in ICU are Gram negative pathogens. Etiopathogenesis.In the critical patient, several factors are combined making them especially vulnerable to infections. Clinical manifestations. Depends on the location of the infection.Diagnosis. It must be early due to its increased mortality.Prognosis. Nosocomial infections are associated with an increase in mortality and in the length of stay.

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Managing CAP in the ICU

Cited by 3 publications

References 43 publications

Biomarker Value in the Diagnosis of Community-Acquired Pneumonia with Concomitant Chronic Heart Failure

Biomarker Value in the Diagnosis of Community-Acquired Pneumonia with Concomitant Chronic Heart Failure

Measuring the intensive care experience of intensive care unit patients: A cross-sectional study in western China

Infecciones en el paciente crítico

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