“…Acetaminophen presents itself as a viable therapeutic option for patients who are experiencing gastrointestinal ulcers or asthma associated with the use of aspirin (Kacso & Terézhalmy, 1994 ; Pergolizzi et al, 2020 ). Previous studies have assessed whether NSAIDs, such as celecoxib, valdecoxib, ibuprofen, flurbiprofen, lornoxicam, etoricoxib, and opioid‐containing drugs (such as oxycodone) (Benetello et al, 2007 ; Demirbas et al, 2019 ; Franco‐de la Torre et al, 2021 ; Isola, Alibrandi, et al, 2019 ; Isola, Matarese, Ramaglia, Cicciù, et al, 2019 ; Pruskowski et al, 2019 ; Rajanna & B R, 2021 ; Xie et al, 2020 ), are the most effective analgesics in patients who underwent mandibular third molar extractions. Notably, flurbiprofen, lornoxicam, and a phytotherapeutic compound consisting of baicalin, bromelain, and escin have been identified as efficacious in managing pain following third molar surgery (Isola, Alibrandi, et al, 2019 ; Isola, Matarese, Ramaglia, Iorio‐Siciliano, et al, 2019 ).…”