Managing a small burn

Antrum, John Henry George; Galloway, Jennifer Eleanor; Anwar, Mohammed; Hodson, Sophie Louise

doi:10.1136/bmj-2021-068812

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…[ 2 ] In addition, complications such as infection, hypothermia, as well as bone and joint problem are usually accompanied with burn injuries, which will further restrict the healing process. [ 3 ] Burn injuries also frequently result in the damage and loss of skin appendages, including peripheral nerves and hair follicle bulges, which may lead to a lack of signaling cues necessary to initiate the repairing process. [ 4 ] Management of burns involves not only wound care and infection prevention but also skin appendages regeneration that promotes optimal healing and functional recovery.…”

Section: Introductionmentioning

confidence: 99%

Green‐Prepared Magnesium Silicate Sprays Enhance the Repair of Burn‐Skin Wound and Appendages Regeneration in Rats and Minipigs

Xu,

Zhang,

Dai

et al. 2023

Adv Funct Materials

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Bioceramics provide promising tactics for wound healing, yet the on‐shelf products are still unmet, especially for skin appendages regeneration. Herein, the inorganic magnesium silicate sprays (MSS) as mineral factors to overcome the existing challenges is proposed. Results indicate MSS can be synthesized by a green method without organic solvents, templates, calcination, and harmful by‐products. With amorphous phase, nanoscale, and high specific surface area, MSS reveal an improved pH‐responsive degradability and excellent bioactivity for cell proliferation and migration. In rats, MSS display a dose‐dependent effect on accelerating burn‐wound repair via regulating the expressions of iNOS and IL‐10 to attenuate inflammation, elevating the expressions of CD31 and α‐SMA to improve vascularization, and boosting collagen deposition without ectopic calcification. The released Mg and Si ions synergistically potentiate the expressions of Gap43, Tubb3, and K19, suggesting the regeneration of peripheral nerves and hair follicles. These superior features are further verified by comparisons with commercial products, Dermlin® and 45S5 bioglass®, in both rats and minipigs. Motivated by these findings, three MSS‐based formulations of band‐aid patch, adhesive hydrogel, and antibacterial sprays are devised for specific scenarios. Taken together, this proof‐of concept study provides a promising bioactive mineral for future clinical skin wound repair and functional appendages regeneration.

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Section: Introductionmentioning

confidence: 99%