Management trends and outcomes of pineal germinoma in a multi-institutional Australian cohort

Stephens, S. D. G.; Kuchel, Anna; Cheuk, Robyn; Alexander, Hamish; Robertson, Thomas; Rajah, Thulasi; Tran, Quan T.; Inglis, Po-Ling

doi:10.1016/j.jocn.2021.05.006

Cited by 3 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…GCTs account for half of all tumors detected in the pineal area, with pure germinomas accounting for the majority [ 2 ]. Primary germ cell tumors constitute 0.4% of all CNS tumors and are most commonly detected in children aged 10-14 [ 3 ]. With a male predominance incidence of primary CNS GCT is 0.10-0.17 per 100,000 population.…”

Section: Introductionmentioning

confidence: 99%

“…Germinoma is the most prevalent histological subtype, with 50%-60% of cases arising in the pineal recess. The most common sites where Yolk sac tumor and Germinoma are Suprasellar (30%), bifocal suprasellar and pineal (10%-15%), basal ganglia (5%), and multifocal suprasellar and pineal (10%-15%) [ 3 ]. Patients with pineal region tumors commonly present with symptoms related to raised intracranial pressure and/or hydrocephalus, such as headache, vomiting, nausea, lethargy, somnolence and papilledema [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Diverse opinions exist on the appropriate radiation dose and volume for disease control and recurrence prevention while balancing adverse effects on cognitive and endocrine function [ 5 ]. However, maximal resection has the potential to increase diagnostic accuracy as well as the outcome [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mixed germ cell tumor of the pineal gland in a pediatric patient

Kabashi

Ahmetgjekaj

Harizi

et al. 2022

Radiology Case Reports

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mixed germ cell tumor of the pineal gland in a pediatric patient

Kabashi

Ahmetgjekaj

Harizi

et al. 2022

Radiology Case Reports

View full text Add to dashboard Cite

Depression and Nystagmus as the Rare Masquerading Presentations of Pineal Germinoma

Wong¹,

Cheng²,

Pauzi³

et al. 2023

Cureus

View full text Add to dashboard Cite

Convergence-retraction nystagmus alongside behavioral changes can be rare manifestations of a potentially life-threatening midbrain lesion. After experiencing headaches for three months, a 13-year-old boy was diagnosed with depression due to exhibiting reduced speech, hypersomnia, and psychomotor slowing for three weeks. It was preceded by headache for three months. Examination revealed visual acuity of 6/6 bilaterally, convergence-retraction nystagmus worst on upgaze, limited bilateral ocular motility in upgaze, and light-near dissociation on pupil examination, all of which point towards Parinaud’s syndrome. However, there was no lid retraction to suggest Collier’s sign. Fundus examination revealed papilledema. Magnetic resonance imaging showed a large pineal mass extending to both thalami, dilated ventricles due to obstructive hydrocephalus, and cerebral edema. An urgent external ventricular drain was inserted, and biopsy revealed pineal gland germinoma. Chemotherapy and radiotherapy resulted in adequate tumor shrinkage. This case report highlights that subacute behavioral changes may mask a potentially life-threatening intracranial tumor, especially when associated with abnormal eye movement.

show abstract

Neoadjuvant Chemotherapy Approach to Pineal Germinoma: A Case Report

Bazzi,

Saad,

Bazzi

et al. 2024

Cureus

View full text Add to dashboard Cite

Intracranial germ cell tumors (GCTs) are rare malignant tumors with a peak incidence around puberty. The pineal region is the most commonly involved area of all intracranial GCTs. Due to the heterogeneous tumor origin, subtypes, and presentation, diagnosis and management are challenging. Complicated pineal germinomas are rarely reported in the literature. Here, we report a rare case of pineal germinoma with hydrocephalus and discuss the potential treatment approach. A 20-year-old boy presented to the hospital with vomiting and a decreased level of consciousness. The brain magnetic resonance imaging (MRI) revealed a pineal tumor. A ventriculoperitoneal shunt was placed to relieve the increased intracranial pressure. The patient underwent a suboccipital craniotomy with excisional biopsy of the pineal region tumor due to its critical location, as imaging studies alone may not be sufficient to establish a definitive diagnosis. Although there has been a rise in reported cases of germinoma tumors, there is currently no standardized therapeutic approach for treating them. Therefore, more randomized controlled cohort studies are necessary to evaluate potential treatments and develop a therapeutic approach.

show abstract

Management trends and outcomes of pineal germinoma in a multi-institutional Australian cohort

Cited by 3 publications

References 34 publications

Mixed germ cell tumor of the pineal gland in a pediatric patient

Mixed germ cell tumor of the pineal gland in a pediatric patient

Depression and Nystagmus as the Rare Masquerading Presentations of Pineal Germinoma

Neoadjuvant Chemotherapy Approach to Pineal Germinoma: A Case Report

Contact Info

Product

Resources

About