Management strategies of enterovirus D68 outbreaks: current perspectives

Milhano, Natacha; Borge, Kaja Sverdrup; Bragstad, Karoline

doi:10.2147/vaat.s140376

Cited by 2 publications

(2 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…EV-D68 belongs to one of the four groups of enterovirus genus that infect humans. It has a 7.6 kb ( +) sense ssRNA as genome with an ORF coding for four structural (VP1 to VP4) and seven non-structural proteins (2A to 2C and 3A to 3D) flanked by 5′ and 3′ Untranslated region (3′UTRs) either side with a 3' poly adenylation (poly(A)) tail [90,92]. VP1 viral protein helps to detect different serotypes due to the presence of a serotype-specific loop and proteins 2C and 3C have been targeted for antiviral therapy because of their role in the virus infection cycle.…”

Section: Human Enteroviruses (Ev-d68)mentioning

confidence: 99%

See 1 more Smart Citation

Respiratory illness virus infections with special emphasis on COVID-19

et al. 2022

View full text Add to dashboard Cite

Viruses that emerge pose challenges for treatment options as their uniqueness would not know completely. Hence, many viruses are causing high morbidity and mortality for a long time. Despite large diversity, viruses share common characteristics for infection. At least 12 different respiratory-borne viruses are reported belonging to various virus taxonomic families. Many of these viruses multiply and cause damage to the upper and lower respiratory tracts. The description of these viruses in comparison with each other concerning their epidemiology, molecular characteristics, disease manifestations, diagnosis and treatment is lacking. Such information helps diagnose, differentiate, and formulate the control measures faster. The leading cause of acute illness worldwide is acute respiratory infections (ARIs) and are responsible for nearly 4 million deaths every year, mostly in young children and infants. Lower respiratory tract infections are the fourth most common cause of death globally, after non-infectious chronic conditions. This review aims to present the characteristics of different viruses causing respiratory infections, highlighting the uniqueness of SARS-CoV-2. We expect this review to help understand the similarities and differences among the closely related viruses causing respiratory infections and formulate specific preventive or control measures.

show abstract

Section: Human Enteroviruses (Ev-d68)mentioning

confidence: 99%

“…Proper understanding of the host-viral interaction, the evolution of the virus, and periodic surveillance is required to manage outbreaks. Supportive care remains the sole strategy for treatment unless requiring ventilator support and corticosteroid administration in severe conditions [92,99].…”

Section: Human Enteroviruses (Ev-d68)mentioning

confidence: 99%

Respiratory illness virus infections with special emphasis on COVID-19

et al. 2022

View full text Add to dashboard Cite

show abstract

Enterovirus D-68 Molecular Virology, Epidemiology, and Treatment: an Update and Way Forward

Ebada

Fayed

Alkanj

et al. 2021

IDDT

View full text Add to dashboard Cite

: Enterovirus D68 (EV-D68) is a single-stranded positive-sense RNA virus, and it is one of the family Picornaviridae. Except for EV-D68, the family Picornaviridae has been illustrated in literature. EV-D68 was first discovered and isolated in California, USA, in 1962. EV-D68 has resulted in respiratory disorders’ outbreaks among children worldwide, and it has been detected in cases of various neurological diseases such as acute flaccid myelitis (AFM). A recent study documented a higher number of EV-D68 cases associated with AFM in Europe in 2016 compared to the 2014 outbreak. EV-D68 is mainly diagnosed by quantitative PCR, and there is an affirmative strategy for EV-D68 detection by using pan-EV PCR on the untranslated region and/or the VP1 or VP2, followed by sequencing of the PCR products. Serological tests are limited due to cross-reactivity of the antigens between the different serotypes. Many antiviral drugs for EV-D68 have been evaluated, and showed promising results. In our review, we discuss the current knowledge about EV-D68 and its role in the development of AFM.

show abstract

Management strategies of enterovirus D68 outbreaks: current perspectives

Cited by 2 publications

References 49 publications

Respiratory illness virus infections with special emphasis on COVID-19

Respiratory illness virus infections with special emphasis on COVID-19

Enterovirus D-68 Molecular Virology, Epidemiology, and Treatment: an Update and Way Forward

Contact Info

Product

Resources

About