“…Therefore, the study of Chai-Coetzer was likely underpowered to demonstrate a difference in the PAP adherence metric. Additionally, as noted by Weingarten and Basner, 8 study withdrawal was 2-3 fold higher in primary care versus specialist groups, with nearly half of the withdrawals in the primary care group due to PAP intolerance. Demonstrating non-inferior reduction in subjective sleepiness as determined by ESS in OSA in a tightly controlled protocol managed by primary care physicians and allied health providers relative to sleep specialist should not be interpreted as providing equivalent PAP adherence and cardiovascular risk reduction.…”