Management patterns and outcomes of patients hospitalized with diabetic foot ulcers at one tertiary care hospital

Exploring the pathogenesis of osteomyelitis accompanied by diabetic foot ulcers using microarray data analysis

“…[42] Their findings suggest that IL-1β, IFN-γ, and TNF-α act cohesively and may provide an important proinflammatory link between osteomyelitis and DFU. [43] Due to the strong genetic similarities between osteomyelitis and DFU, in contrast to the aims of previous studies, our work focuses more on exploring TFs of hub genes and regulatory genes common to osteomyelitis and DFU. We established a complex network of protein interactions to further screen key pivotal genes by common DEGs.…”

“…[ 42 ] Their findings suggest that IL-1β, IFN-γ, and TNF-α act cohesively and may provide an important proinflammatory link between osteomyelitis and DFU. [ 43 ]…”

Diabetic foot ulcers: a growing global health emergency in the COVID-19 era

“…Antibiotic prescription occurred in 77% of patients with osteomyelitis and was not based on culture. According to the authors, the prescription rates for anti-MRSA and antipseudomonal antibiotics were probably higher than necessary [ 1 ].…”

“…The evidence base for many aspects of foot ulcer treatment in people with diabetes is weak and good-quality research is needed, especially studies for routine clinical care such as the one discussed [ 1 ]. The principles of good standard care include a formal assessment of the ulcer and surrounding skin at each clinical review; the necessary discharge, with a detailed description of the type and an evaluation of its effectiveness; debridement of the wound surface, which can be surgical (either in the clinic or in an operating room) or non-surgical; selection of appropriate care products; appropriate antimicrobial therapy (only for clinically infected wounds); attention to nutrition and self-care; try to achieve optimal glycemic control; evaluation of peripheral arterial disease, with consideration of revascularization when appropriate; and close observation continues with appropriate management adjustment [ 6 ].…”

“…Despite numerous management guidelines, there appears to be significant deviation from standard care recommendations, reflecting the complex nature of these patients in real world practice. Future interventions should aim at standardization to improve outcomes [ 1 ].…”