Management, outcome and prognostic factors of metastatic gastric cancer

Karrit, S.; Belaid, Imtinène; Ezzairi, Faten; Ghali, A.; Bedioui, A.; Bouzid, N.; Mabrouk, Mohamed Ben; Bouzaiene, F.; Cheikh, Y. Ben; Chabchoub, I.; Hochlaf, Makrem; Fatma, Leïla Ben; Ahmed, Slim Ben

doi:10.1093/annonc/mdy151.077

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“…The incidence and morbidity of gastric cancer remained high worldwide 11 . Thanks to the development of a number of treatments including targeted drugs, immunotherapy, and radiation, the median survival time had been prolonged all the time 12 - 16 . However, one-third and one-fifth of early death which was defined as death came up within 3 months occurred in the SEER cohort and the Chinese cohort of this study, respectively.…”

Section: Discussionmentioning

confidence: 99%

A Predictive Nomogram for Early Death of Metastatic Gastric Cancer: A Retrospective Study in the SEER Database and China

et al. 2020

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Background: To identify associated risk factors and develop a predictive nomogram for the early death of metastatic gastric cancer patients. Methods: A total of 4575 patients in the SEER cohort and 220 patients in the Chinese cohort diagnosed with metastatic gastric cancer in our Cancer Center were obtained. Univariate and multivariate logistic regression models were used to identify independent risk variables for early death. A predictive nomogram and a web-based probability calculator were developed and then validated by receiver operating characteristics (ROCs) curve and calibration plot in a Chinese cohort. Results: Eight independent variables, including race, grade, surgery, chemotherapy, and metastases of bone, brain, liver, lung were recognized by using univariate and multivariate logistic regression models for identifying independent risk variables of early death about metastatic gastric cancer patients. By comprising these variables, a predictive nomogram and a web-based probability calculator were constructed in the SEER cohort. Then, it could be validated well in the Chinese cohort by receiver operating characteristics (ROCs) curve and calibration plot. Conclusion: Using this nomogram model provided an insightful and applicable tool to distinguish the early death of metastatic gastric cancer patients.

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Section: Discussionmentioning

confidence: 99%