Management Options for Hot Flashes in Cancer Patients

Moraska, Amanda R.; Loprinzi, Charles L.

doi:10.1002/9781118590638.ch13

Cited by 3 publications

(14 citation statements)

References 133 publications

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“…Only 21% of women experiencing HFs were receiving treatment for them, and most participants described no knowledge or poor knowledge of HF treatment options . Patients taking anastrozole or other aromatase inhibitors also experience a higher incidence and severity of HFs than the general population …”

Section: Introductionmentioning

confidence: 99%

“…For example, gabapentin or antidepressants such as selective serotonin reuptake inhibitors or serotonin‐norepinephrine reuptake inhibitors may cause nausea, drowsiness, dizziness, dry mouth, or headache, and many women decline selective serotonin reuptake inhibitors/serotonin‐norepinephrine reuptake inhibitors because of the associated stigma of taking an antidepressant . If HF symptoms are severe and cannot be managed effectively, some patients may choose to discontinue their cancer treatments …”

Section: Introductionmentioning

confidence: 99%

“…Hot flashes (HFs), a sensation of heat flushing over the skin, 1,2 are a common complaint among cancer patients undergoing treatment as well as cancer survivors, particularly those who have undergone oophorectomy, orchiectomy, chemotherapy, and/or hormone therapy. 3 HFs can be severe and are often accompanied by sweating, palpitations, dizziness, nausea, chills, fatigue, poor sleep, or mood disturbances. These symptoms may persist for years and can affect work, social activities, concentration, energy levels, and overall quality of life.…”

Section: Introductionmentioning

confidence: 99%

“…5 Patients taking anastrozole or other aromatase inhibitors also experience a higher incidence and severity of HFs than the general population. 3,6,7 Effective treatment options for HFs are particularly limited for women with estrogen receptor-positive disease, and some treatments may not provide complete relief or may have unpleasant side effects. For example, gabapentin or antidepressants such as selective serotonin reuptake inhibitors or serotonin-norepinephrine reuptake inhibitors may cause nausea, drowsiness, dizziness, dry mouth, or headache, and many women decline selective serotonin reuptake inhibitors/serotonin-norepinephrine reuptake inhibitors because of the associated stigma of taking an antidepressant.…”

Section: Introductionmentioning

confidence: 99%

“…8 If HF symptoms are severe and cannot be managed effectively, some patients may choose to discontinue their cancer treatments. 3,[8][9][10] Because of a lack of treatment options, cancer patients often turn to integrative therapies to help manage HF symptoms, with many adding acupuncture to their treatment plan. 11 According to the theory of traditional Chinese medicine, the body's Qi (pronounced "chee") or vital energy can be stimulated by the insertion of small needles into specific body locations.…”

Section: Introductionmentioning

confidence: 99%

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Systematic review of acupuncture to control hot flashes in cancer patients

Garcia

Graham-Getty

Haddad

et al. 2015

Cancer

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Hot flashes (HFs) are a common side effect of cancer treatment. The purpose of this systematic review was to evaluate evidence related to the use of acupuncture for HFs in cancer patients. EMBASE, MEDLINE, Cochrane (all databases), PubMed, the Cumulative Index to Nursing and Allied Health Literature, and Scopus were searched from their inception through December 2014. Included studies had to be randomized controlled trials with a usual-care and/or placebo comparison group that investigated acupuncture to treat HFs in cancer patients. No language limits were applied. The risk of bias (ROB) was rated as low, high, or unclear according to Cochrane criteria. Both within-group and between-group changes were evaluated. Four hundred two items were identified, and 192 duplicates were omitted; this left 210 publications to be screened. Eight studies met the inclusion criteria, and all involved women with breast cancer. All studies showed significant within-group improvement from the baseline for true acupuncture (TA). One study showed significant improvement in favor of TA over sham acupuncture (SA; P < .001), 1 study found in favor of TA over SA for nighttime HFs only (P = .03), and 1 study found in favor of TA over SA or untreated controls (P < .01 and P < .001, respectively). Between-group (TA vs SA) effect size (ES) estimates for daytime and nighttime HFs were calculated (ES range, 0.04–0.9) whenever possible. No studies were rated with a low ROB. In conclusion, the current level of evidence is insufficient to either support or refute the benefits of acupuncture for the management of HFs in cancer patients. Future studies should provide within-group and between-group ES estimates in addition to P values.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Systematic review of acupuncture to control hot flashes in cancer patients

Garcia

Graham-Getty

Haddad

et al. 2015

Cancer

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The pharmacological and hormonal therapy of hot flushes in breast cancer survivors

et al. 2015

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The side effects of oncological treatment, which appear during or after therapy, are sometimes very annoying for patients and are not adequately treated by physicians. Among the symptoms experienced by breast cancer patients are hot flushes, which result from a natural or cancer therapy-induced menopause. The intensity of hot flushes in breast cancer patients may be more severe than those experienced by women undergoing a natural menopause. Taking into account the incidence of breast cancer and long-lasting hormone-suppression therapies, the problem of hot flushes will affect many women. Hormonal replacement therapy, the most effective therapeutic means for alleviating hot flushes, is usually contraindicated for breast cancer patients. For intense and severe hot flushes, pharmacological treatment using agents from a group of selective serotonin reuptake inhibitors and serotonin and norepinephrine reuptake inhibitors such as venlafaxine or citalopram may be introduced. Other agents from different pharmacological groups, such as clonidine, gabapentin, or pregabalin, have also proved to be effective in treating hot flushes. The efficacy of phytoestrogens has not been proven in randomized clinical trials. The importance of the placebo effect in decreasing vasomotor symptoms has also been reported in many research papers. Educating breast cancer patients in lifestyle changes which decrease the frequency and intensity of vasomotor symptoms can offer significant help too. This paper reviews the current state of research in order to assess the options for the treatment of hot flushes in breast cancer survivors.

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Prevalência de ondas de calor e fatores de risco associados em mulheres no climatério

Fonseca¹

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Management Options for Hot Flashes in Cancer Patients

Cited by 3 publications

References 133 publications

Systematic review of acupuncture to control hot flashes in cancer patients

Systematic review of acupuncture to control hot flashes in cancer patients

The pharmacological and hormonal therapy of hot flushes in breast cancer survivors

Prevalência de ondas de calor e fatores de risco associados em mulheres no climatério

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