Management of women with cervical cancer precursor lesions

Cox, J. Thomas

doi:10.1016/s0889-8545(02)00047-5

Cited by 17 publications

(9 citation statements)

References 102 publications

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“…New biomarkers that could predict which LSIL are at a highest risk for development of HSIL appear to be on prospect and may make the management of LSIL as clear as present guidelines for HSIL [15]. In the present study we evidenced the behavior of an important biomarker in HPV carcinogenesis process.…”

Section: Discussionmentioning

confidence: 53%

“…Understanding that LSIL lesions are not always true cervical cancer precursors has raised expectant management of women with these lesions. However, management approaches are still in disadvantage by the incapacity to better predict who is at risk for HSIL and cancer and who is not; particularly in LSIL treatment [15].…”

Section: Discussionmentioning

confidence: 99%

“…Currently, medical management of low-grade squamous intraepithelial lesions (LSIL) is variable [14,15]. Biomarkers could contribute to evidence indicators of more serious injuries or to their resolution.…”

Section: Introductionmentioning

confidence: 99%

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Expression analysis of transglutaminase 2 in premalignant lesions of the cervix

et al. 2017

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Background: The medical management of low-grade squamous intraepithelial lesions (LSIL) is variable, thus a biomarker could assist with the clinical conduct. Type 2 transglutaminase (TG2) has been proposed as a cellular-interfering factor in HPV infection and carcinogenesis. Therefore, this study has the objective of evaluating TG2 expression in LSIL and highgrade squamous intraepithelial lesions (HSIL) and of relating it to the different HPV viral types. Methods: This study included 146 patients with suspected LSIL or HSIL detected in routine conventional Papanicolaou tests. The presence of HPV DNA and viral typing was defined by the polymerase chain reaction method (PCR). TG2 Immunohistochemistry (IHC) was conducted according to the manufacturer's instructions; IHC was carried out in an Autosteiner-Link 48 Dako equipment. IHC quantitation was performed by relative expression and by using the software Image J. Qualitative variables, such as frequencies and proportions, were compared by using the χ2 test for independent samples. For comparison of the qualitative to the quantitative data, nonparametric Mann-Whitney test was used.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

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Expression analysis of transglutaminase 2 in premalignant lesions of the cervix

et al. 2017

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“…Al tomar la actitud de no tratar la NIE I (visión colposcópica satisfactoria) y seguirlas con tratamiento expectante por 2 años, hay que considerar que las que terminan el seguimiento son el 37 %, el 30% se transfiere a otros lugares y el 32,9% se pierde del seguimiento (8). Por este motivo en nuestro Servicio se práctica diatermo o criocoagulación a las lesiones de bajo grado (9).…”

Section: Discussionunclassified

“…En general los procedimientos ablativos no abarcan más de 4 a 5 mm en profundidad, tampoco permiten el estudio histológico, por este motivo, existe un riesgo de no diagnosticar lesiones invasoras ocultas o subtratar lesiones de alto grado con compromiso de canal (8). La lesión residual es mucho mas frecuente en el cono con compromiso de margen endocervical positivo que en el compromiso de borde exocervical (3,11,12).…”

Section: Discussionunclassified