Management of vulvar cancers

Hullu, Joanne A. de; Avoort, Irene A.M. van der; Oonk, Maaike H. M.; Zee, Ate G.J. van der

doi:10.1016/j.ejso.2006.03.035

Cited by 59 publications

(43 citation statements)

References 52 publications

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“…We also found that the incidence increased with age, as has been suggested by other authors [6,13,14,15,16]. However, our patients ranged in age from 15 to 98 years.…”

Section: Discussionsupporting

confidence: 70%

Characterization of Sociodemographic and Clinicopathological Features in Brazilian Patients with Vulvar Squamous Cell Carcinoma

Maia

Cestari

Lavorato-Rocha

et al. 2012

Gynecol Obstet Invest

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Aim: To investigate sociodemographic and clinical-epidemiological profiles of patients with vulvar carcinoma in São Paulo, the largest city of Brazil, to establish a more consistent profile of these features once the incidence of vulvar carcinoma has risen considerably. Data regarding the epidemiological aspects of this tumor are scarce. Methods: A retrospective study was performed using 300 medical records from patients diagnosed with squamous cell carcinoma of the vulva and surgically treated at A.C. Camargo Hospital in São Paulo, Brazil, from 1978 to 2009. Results: The median age of onset was 70 years, ranging from 15 to 98 years, and most women were white (88.51%). Most patients (83.54%) had little or no schooling and had the lowest survival curve. Many patients were diagnosed in the early stages of the disease (57.09% FIGO IB), 59% had complications due to surgery and 43.71% had disease recurrence, of which about 70% died. Conclusions: Our study adds 300 Brazilian cases of vulvar carcinoma to the world literature. Given the high rate of disease recurrence and mortality in Brazil, we conclude that regular gynecologic evaluation and educational policies should be reinforced in order to raise awareness for vulvar cancer.

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“…We also found that the incidence increased with age, as has been suggested by other authors [6,13,14,15,16]. However, our patients ranged in age from 15 to 98 years.…”

Section: Discussionsupporting

confidence: 70%

Characterization of Sociodemographic and Clinicopathological Features in Brazilian Patients with Vulvar Squamous Cell Carcinoma

Maia

Cestari

Lavorato-Rocha

et al. 2012

Gynecol Obstet Invest

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“…More recently, radical local excision, with inguinal lymph node dissection based on depth of invasion has become more widely used [6,[8][9][10]. Adjuvant chemoradiation is commonly recommended as primary therapy for women with large tumors, as well as for patients who undergo primary surgery and are found to have close or positive margins or with metastatic disease in inguinal lymph nodes [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Demographic, clinical, and treatment trends among women diagnosed with vulvar cancer in the United States

Stroup

Harlan

Trimble

2008

Gynecologic Oncology

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Objective-Describe the treatment and survival patterns among a population-based sample of vulvar cancer patients diagnosed in the U.S. in 1999.Methods-Cases were identified for the National Cancer Institute's Patterns of Care Study (POC) using Surveillance, Epidemiology, and End Results Program (SEER). A stratified random sample of non-Hispanic white, non-Hispanic black, and Hispanic women age 20 and older was selected from cases reported by eleven SEER registries. Analyses of the association between vulvar cancer and key demographic, clinical, and hospital characteristics by stage were performed. Cox proportional hazards was used to estimate the odds of death due to cancer. All estimates were weighted, and analyses were conducted with SUDAAN.Results-90% of cases were diagnosed with in situ or early stage invasive disease. Older patients were more likely to present at advanced stages. 25% of women with Stage III-IV vulvar cancer received chemotherapy plus radiation. We noted widespread use of radical local excision among women with Stage I/II cancer, but 46%-54% with invasive disease underwent a radical or total vulvectomy. Factors associated with cancer death were limited to age and stage. Women 75 years and older were at higher risk compared to women aged 20-49 and the risk of death increased with advancing stage.Conclusions-Vulvar cancer is diagnosed at early stages. Late stage disease is associated with a significant increase in mortality. Radical surgery was still commonly performed in 1999. Radiation was more common in women diagnosed at late stage, while the use of chemoradiation remained limited. KeywordsVulva; vulvar; cancer; patterns of care; treatment Correspondence: Antoinette M. Stroup, PhD, Utah Cancer Registry, University of Utah, 650 Komas Drive, Suite 106B, Salt Lake City, Utah 84108, Nan.Stroup@hsc.utah.edu, Tel: (801) 581-8407, Fax: (801) 581-4560. Article Précis Describe treatment and survival among a population-based sample of women in the US diagnosed in 1999 with vulvar cancer and treated in the community.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers

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“…Los resultados más alentadores en relación con la exenteración pélvica por neoplasias ginecológicas se ha obtenido en el cáncer cervical; en el cáncer vulvar la supervivencia a cinco años es inferior al 40% 13 . El caso que presentamos fue tratado con quimioterapia y radioterapia, aunque hubo progresión de la enfermedad al finalizar el tratamiento, progresión documentada en la literatura médi-ca que se presenta en el 14% de los casos, como reportó Tans en un análisis de 28 pacientes tratados con quimioterapia y radioterapia con cáncer de vulva localmente avanzado, con seguimiento de 42 meses, donde 4 de 28 presentaron progresión de la enfermedad 12 .…”

Section: Discussionunclassified

Reconstrucción perineal con doble colgajo de gracilis en cáncer de vulva. Reporte de caso y revisión de la literatura

Luna-Merlos¹,

Salazar-Campos²,

Meneses-García³

et al. 2022

GAMO

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Management of vulvar cancers

Cited by 59 publications

References 52 publications

Characterization of Sociodemographic and Clinicopathological Features in Brazilian Patients with Vulvar Squamous Cell Carcinoma

Characterization of Sociodemographic and Clinicopathological Features in Brazilian Patients with Vulvar Squamous Cell Carcinoma

Demographic, clinical, and treatment trends among women diagnosed with vulvar cancer in the United States

Reconstrucción perineal con doble colgajo de gracilis en cáncer de vulva. Reporte de caso y revisión de la literatura

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