Management of Villous Adenomas of the Colon and Rectum

Nicoloff, Demétre M.; Ellis, Cassius M. C.; Humphrey, Edward W.

doi:10.1001/archsurg.1968.01340020118014

Cited by 22 publications

(4 citation statements)

References 7 publications

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confidence: 85%

“…In the Ochsner Clinic series of 217 cases, only 2 occurred in the caecum (Hanley et al, 1971). Similar findings have been reported in other series (Liechty and Soper, 1968;Nicoloff et al, 1968;Welch and Welch, 1976).Primary malignant tumours of the vermiform appendix are rare and approximately 85 per cent of these are carcinoids and 11 per cent are adenocarcinomas (Morson and Dawson, 1974). Villous adenomas of the appendix are even more rare, with only 42 cases described up until 1976up until (Hameed, 1966Vander and Mandell, 1968;Jablokow and Dieter, 1970;Ho and Rosenman, 1975;Wolff and Ahmed, 1976).…”

supporting

confidence: 76%

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Villous adenoma causing acute appendicitis

Munk

1977

Journal of British Surgery

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Acute appendicitis is the most common of surgical emergencies. However, it is very unusual to find a benign neoplastic lesion causing appendicitis. Adenomas of the caecum or the appendix are rare and very few cases of these associated with appendicular inflammation have been described. This report presents a case of acute appendicitis with perforation resulting from obstruction by an adenoma. The management of the condition is discussed.

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confidence: 85%

supporting

confidence: 76%

Villous adenoma causing acute appendicitis

Munk

1977

Journal of British Surgery

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“…Similarly high incidences have been reported by Olson and Davis (1969). Nicoloff et al (1968), however, concluded that there is no relation of size to malignancy. The difficulty in obtaining the correct diagnosis by biopsy is well known (Boling and Finch, 1963).…”

Section: Discussionsupporting

confidence: 52%

Villous adenoma of the colon and rectum

Evans

Imahori

Liu

1972

Journal of Surgical Oncology

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One hundred and four cases of villous tumors during a 19‐year period are reported, including 38 cases of villous adenoma and 40 cases of carcinoma arising in villous adenoma. These tumors are found in the rectum and rectosigmoid of patients who are mostly 50 years old or older. The majority of these tumors are malignant and the accuracy of diagnosis by biopsy is rather low. Villous tumors of the colon and rectum should be treated as cancerous growths, and radical resection is the preferred treatment.

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“…Radiologists must maintain prudence to avoid identification of false lesions 11 ; nevertheless, it was a significant finding that 46% of the polyps had a surface labeling of adherent contrast. Of special clinical note, too, was that polyps with a villous component, associated with a greater risk of malignancy, 12 had 77% adherent contrast. Thus, enhanced polyp specificity outlines the motivation to design a marker.…”

Section: Discussionmentioning

confidence: 99%

Rh-I-UEA-1 Polymerized Liposomes Target and Image Adenomatous Polyps in the APC^Min/+ Mouse Using Optical Colonography

Roney

Xie

et al. 2011

Mol Imaging

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Mutated adenomatous polyposis coli (APC) genes predispose transformations to neoplasia progressing to colorectal carcinoma (CRC). Early detection facilitates clinical management and therapy. Novel lectin-mediated polymerized targeted liposomes (Rh-I-UEA-1), with polyp specificity and incorporated imaging agents, were fabricated to locate and image adenomatous polyps in APCMin/+ mice. The biomarker α-L-fucose covalently joins liposomal conjugated lectin ulex euroapeus agglutinin (UEA-1), via glycosidic linkage to the polyp mucin layer. Multispectral optical imaging (MSI) corroborated a global perspective of specific binding (Rhodamine B 532 nm emission, 590–620 nm excitation) of targeted Rh-I-UEA-1 polymerized liposomes to polyps with 1.4× fold labeling efficiency. High-resolution co-registered optical coherence tomography (OCT) and fluorescence molecular imaging (FMI) reveal spatial correlation of contrast distribution and tissue morphology. Freshly excised APCMin bowels were incubated with targeted liposomes (UEA-1 lectin), control liposomes (no lectin), or Omnipaque and imaged by the three techniques. CT quantitative analyses did not confirm targeted liposomes more strongly bound polyps than nontargeted liposomes or Omnipaque alone. OCT, with anatomical depth capabilities, along with the co-registered FMI, substantiated Rh-I-UEA-1 liposome binding along the mucinous polyp surface. UEA-1 lectin denotes α-L-fucose biomarker carbohydrate expression at the mucin glycoprotein layer; Rh-I-UEA-1 polymerized liposomes target and image adenomatous polyps in APCMin mice.

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Management of Villous Adenomas of the Colon and Rectum

Cited by 22 publications

References 7 publications

Villous adenoma causing acute appendicitis

Villous adenoma causing acute appendicitis

Villous adenoma of the colon and rectum

Rh-I-UEA-1 Polymerized Liposomes Target and Image Adenomatous Polyps in the APC^Min/+ Mouse Using Optical Colonography

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Management of Villous Adenomas of the Colon and Rectum

Cited by 22 publications

References 7 publications

Villous adenoma causing acute appendicitis

Villous adenoma causing acute appendicitis

Villous adenoma of the colon and rectum

Rh-I-UEA-1 Polymerized Liposomes Target and Image Adenomatous Polyps in the APCMin/+ Mouse Using Optical Colonography

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Product

Resources

About

Rh-I-UEA-1 Polymerized Liposomes Target and Image Adenomatous Polyps in the APC^Min/+ Mouse Using Optical Colonography