Management of Venous Sinus Thrombosis

Sader, Nicholas; Lotbinière-Bassett, Madeleine de; Tso, Michael K; Hamilton, Mark G.

doi:10.1016/j.nec.2018.06.011

Cited by 20 publications

(25 citation statements)

References 20 publications

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“…Cerebral venous sinus thrombosis (CVST), is a rare type of stroke, accounting for 0.5%-1% of all strokes. 1 The disease is more likely to occur in young people, in particular women more regularly. 2 CVST has variable pathogenic factors and complex clinical symptoms, which lack specificity and tend to be misdiagnosed.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of systemic immune–inflammation index in acute/subacute patients with cerebral venous sinus thrombosis

Shen

Gao

et al. 2020

Stroke Vasc Neurol

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ObjectiveTo evaluate the prognosis values of systemic immune–inflammation index (SII) in non-chronic cerebral venous sinus thrombosis (CVST).Methodspatients with CVST, admitted to the First Affiliated Hospital of Zhengzhou University, were retrospectively identified from January 2013 to December 2018. We selected patients in acute/subacute phase from database. Functional outcomes of patients were evaluated with the modified Rankin Scale (mRS)—mRS 3–6 as poor outcomes and mRS 6 as death. The overall survival time was defined as the date of onset to the date of death or last follow-up date. Survival analysis was described by the Kaplan-Meier curve and Cox regression analysis. Multivariate logistic regression analysis assessed the relationship between SII and poor functional outcome. The area under the Receiver Operating Curve curve (AUC) was estimated to evaluate the ability of SII in prediction.ResultsA total of 270 patients were included and their duration of follow-up was 22 months (6–66 months), of whom 31 patients had poor outcomes and 24 patients dead. Cox regression analysis showed that SII (HR=1.304, 95% CI: 1.101 to 1.703, p=0.001) was a predictor of death in non-chronic CVST. Patients with higher SII presented lower survival rates (p=0.003). The AUC of SII was 0.792 (95% CI: 0.695 to 0.888, p=0.040) with a sensitivity of 69.6% and specificity of 80.1%. Subgroups analysis demonstrated that SII was an important predictor of poor outcomes in male (OR=1.303, 95% CI: 1.102 to 1.501, p=0.011) and pregnancy/puerperium female (OR=1.407, 95% CI: 1.204 to 1.703, p=0.034).ConclusionsSII was a potential predictor in the poor prognosis of patients with acute/subacute CVST, especially in male and pregnancy/puerperium female.

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Section: Introductionmentioning

confidence: 99%

Prognostic value of systemic immune–inflammation index in acute/subacute patients with cerebral venous sinus thrombosis

Shen

Gao

et al. 2020

Stroke Vasc Neurol

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“…Patents in our series were diagnosed with CVT via brain CT or CT angiography [19]. Non-contrast brain CT remains the first diagnostic study in cases of lobar intraparenchymal hemorrhages or infarctions that do not follow an arterial distribution [20-21].…”

Section: Discussionmentioning

confidence: 99%

Cerebral Venous Thrombosis at High Altitude: A Retrospective Cohort of Twenty-one Consecutive Patients

Khattar

Sumardi

Zemmar

et al. 2019

Cureus

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Background Cerebral venous thrombosis (CVT) is a rare cerebrovascular disorder, comprising <1% of all strokes. The incidence of CVT is higher in females but a small number of cases suggest that men have a higher risk for CVT in high elevation. The aim of this retrospective cohort study is to investigate this gender-related relationship and to describe the baseline characteristics and treatment outcomes of patients who suffered CVT at high altitude in eastern Nepal. Methods We conducted a retrospective analysis of 21 consecutive patients with CVT at a tertiary care center in Nepal from July 2017 to January 2018. Clinical data, radiologic characteristics, therapeutic strategies, and outcomes were analyzed. The Glasgow Outcome Scale (GOS) at discharge was reported for each patient.

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“…Cerebral Venous Sinus Thrombosis (CVST) is a rare type of stroke, accounting for 0.5-1% of all strokes 1 . Compared to arterial stroke, CVST has highly variable pathogenic factors and complex clinical symptoms, which lacks of speci city and leads to misdiagnosed 2 .…”

Section: Introductionmentioning

confidence: 99%

The Novel Biomarkers-Based HALP (Hemoglobin, Albumin, Lymphocyte and Platelet)-Prognostic Model for Acute and Subacute Patients with Cerebral Venous Sinus Thrombosis: A Retrospective Cohort Study

Shen

Gao

Zhao

et al. 2020

Preprint

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Background and purpose: To evaluate the prognosis values of HALP in acute or subacute cerebral venous sinus thrombosis (CVST), to explore the new prognostic model for CVST.Methods: Consecutive patients who were diagnosed as having acute and subacute CVST were retrospectively investigated. We determined the patients' functional outcomes by modified Rankin Scale (mRS). Multivariate logistic regression analysis was used to assess the relationship between factors and poor functional outcomes. The area under the ROC curve (AUC) was estimated to evaluate the ability of markers and models in predicting clinical prognosis. The prognostic model was presented as nomogram. In addition, the decision curve analysis (DCA) was used to analyze the benefit of this model. Furthermore, survival curves were described by the Kaplan‑Meier analysis. Results: A total of 270 patients were included of which 31 had poor outcome. Multivariable logistic regression analysis demonstrated HALP (OR=0.978, 95%CI: 0.958-0.999, P=0.039) was a protective predictor of outcome. The AUC of HALP was 0.749 (95% CI: 0.633-0.865, P=0.044). DCA demonstrated that this model significantly improved risk prediction at threshold probabilities of CVST at 0 to 85%. Patients with higher HALP (P=0.006) presented higher overall survival rates. Conclusions: HALP may be a potential protective marker in acute and subacute CVST patients. The new prognostic model with HALP had potentially better value for Chinese CVST patients.

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Management of Venous Sinus Thrombosis

Cited by 20 publications

References 20 publications

Prognostic value of systemic immune–inflammation index in acute/subacute patients with cerebral venous sinus thrombosis

Prognostic value of systemic immune–inflammation index in acute/subacute patients with cerebral venous sinus thrombosis

Cerebral Venous Thrombosis at High Altitude: A Retrospective Cohort of Twenty-one Consecutive Patients

The Novel Biomarkers-Based HALP (Hemoglobin, Albumin, Lymphocyte and Platelet)-Prognostic Model for Acute and Subacute Patients with Cerebral Venous Sinus Thrombosis: A Retrospective Cohort Study

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