Management of Upper Gastrointestinal Bleeding in Children

Lirio, Richard A.

doi:10.1016/j.giec.2015.09.003

Cited by 46 publications

(40 citation statements)

References 40 publications

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“…Gastrointestinal bleeding (GIB) is a foremost indication for emergent diagnostic and therapeutic endoscopy requiring prompt, including disease-specific pharmacotherapy[1,2]. Although acute GIB in adults has been exhaustively studied including epidemiology and predictors of adverse outcomes, there is a paucity of the corresponding evidence in children[3,4].…”

Section: Introductionmentioning

confidence: 99%

Mortality associated with gastrointestinal bleeding in children: A retrospective cohort study

Attard¹,

Miller²,

Pant³

et al. 2017

WJG

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AIMTo determine the clinical characteristics of children with gastrointestinal bleeding (GIB) who died during the course of their admission.METHODSWe interrogated the Pediatric Hospital Information System database, including International Classification of Diseases, Current Procedural Terminology and Clinical Transaction Classification coding from 47 pediatric tertiary centers extracting the population of patients (1-21 years of age) admitted (inpatient or observation) with acute, upper or indeterminate GIB (1/2007-9/2015). Descriptive statistics, unadjusted univariate and adjusted multivariate analysis of the associations between patient characteristics and treatment course with mortality was performed with mortality as primary and endoscopy a secondary outcome of interest. All analyses were performed using the R statistical package, v.3.2.3.RESULTSThe population with GIB was 19528; 54.6% were male, overall mortality was 2.07%; (0.37% in patients with the principal diagnosis of GIB). When considering only the mortalities in which GIB was the principal diagnosis, 48% (12 of 25 principal diagnosis GIB mortalities) died within the first 3 d of admission, whereas 19.8% of secondary diagnosis GIB patients died with 3 d of admission. Patients who died were more likely to have received octreotide (19.8% c.f. 4.04%) but tended to have not received proton pump inhibitor therapy in the first 48 h, and far less likely to have undergone endoscopy during their admission (OR = 0.489, P < 0.0001). Chronic liver disease associated with a greater likelihood of endoscopy. Mortalities were significantly more likely to have multiple complex chronic conditions.CONCLUSIONGIB associated mortality in children is highest within 7 d of admission. Multiple comorbidities are a risk factor whereas early endoscopy during the admission is protective.

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Section: Introductionmentioning

confidence: 99%

Mortality associated with gastrointestinal bleeding in children: A retrospective cohort study

Attard¹,

Miller²,

Pant³

et al. 2017

WJG

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“…Upper gastrointestinal bleeding (UGIB) is an important indication for diagnostic and therapeutic endoscopy requiring rapid pharmacotherapy [19] [20].…”

Section: Discussionmentioning

confidence: 99%

Pediatric Esophagogastroduodenoscopy at Yopougon Teaching Hospital: Socio-Demographic Characteristics, Indications, Findings and Management

Kouadio¹,

Eboua²,

Aké-Assi³

et al. 2019

OJPed

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“…Esophageal variceal bleeding in children is rare but can occur, typically in the age range of 7-16 years [16,[61][62][63][64][65]. Elective treatment of esophageal varices should only be performed in specialized centers.…”

Section: Hemorrhage and Variceal Bleeding In Childrenmentioning

confidence: 99%

Pediatric Endoscopy, Update 2020

et al. 2019

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Optimal management of pediatric endoscopy requires a multidisciplinary approach. In most hospitals, endoscopy in pediatric patients is performed by conventional gastroenterologists and only a few centers have specialized pediatric gastroenterologists. This is due to the fact that the number of pediatric gastroenterologists is limited and not all of them are experienced in endoscopic techniques. However, there are also some pediatric centers offering a high-quality and high-volume endoscopy service provided by very experienced pediatric gastroenterologists. Up to now, the literature on pediatric endoscopy is rather sparse. In this article, we describe current knowledge and practice of endoscopic procedures in pediatric patients, which should be relevant for both the adult and pediatric gastroenterologists.

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Management of Upper Gastrointestinal Bleeding in Children

Cited by 46 publications

References 40 publications

Mortality associated with gastrointestinal bleeding in children: A retrospective cohort study

Mortality associated with gastrointestinal bleeding in children: A retrospective cohort study

Pediatric Esophagogastroduodenoscopy at Yopougon Teaching Hospital: Socio-Demographic Characteristics, Indications, Findings and Management

Pediatric Endoscopy, Update 2020

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