Management of Typhoid Fever and Its Complications

Woodward, Theodore E.

doi:10.7326/0003-4819-60-1-144

Cited by 64 publications

(16 citation statements)

References 20 publications

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“…Typhoid fever is a disease which requires new approaches for chemotherapy to overcome the problems of drug resistance and high relapse rates with this illness in different parts of the world (3,11,21,25,43). Plasmid-mediated resistance to chloramphenicol, ampicillin, and other agents presently used to treat systemic salmonellosis is an ever-present problem.…”

Section: Discussionmentioning

confidence: 99%

Oral ciprofloxacin treatment for Salmonella typhimurium infection of normal and immunocompromised mice

Brünner

Zeiler

1988

Antimicrob Agents Chemother

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Oral treatment of Salmonella typhimurium infection with ciprofloxacin was compared with conventional chemotherapy with ampicillin or chloramphenicol in normal (CFW1) and immunocompromised (C57BL/6) mice. Administration of the antibiotics for 12 days reduced the number of bacteria in livers and the mortality of C57BL/6 mice significantly. Ciprofloxacin was considerably more effective than ampicillin in prolongation of the mean survival time of these mice. Similar to conventional chemotherapeutic agents, ciprofloxacin did not prevent fatal disease in most C57BL/6 mice when the treatment lasted 12 days only. On the other hand, ciprofloxacin cured lethal S. typhimurium illness in immunocompromised mice after long-term oral chemotherapy for 26 days at a dosage of 100 mg/kg twice a day. This was not achieved by either ampicillin or chloramphenicol. In normal mice, 12 days of therapy with ciprofloxacin was sufficient for a significant decrease in both the number of viable bacteria in livers and the mortality of lethally infected mice. The results provide a basis for an alternative antibiotic treatment by the oral route in immunocompromised hosts with systemic infections.

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Section: Discussionmentioning

confidence: 99%

Oral ciprofloxacin treatment for Salmonella typhimurium infection of normal and immunocompromised mice

Brünner

Zeiler

1988

Antimicrob Agents Chemother

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“…This study reports 91 cases of typhoid enteric perforation treated at the Hospital Albert Schweitzer, Deschapelles, Accepted for publication July 5,1983 All patients had an acute abdomen and a one-to two-week history of fever, abdominal pain, and constipation typical of typhoid fever. Diarrhea was noted in eight patients (8.8%).…”

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confidence: 99%

Typhoid Perforation of the Intestine

Eustache¹,

Kreis²

1983

Arch Surg

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“…The epidemic eventually involved 80 persons with no fatalities. The analysis of 34 pa¬ tients that follows demonstrates some interesting clinical features of typhoid fever during this outbreak, namely (1) the unusually mild and nonspecific nature of the initial symptoms and signs (which presumably led to many misdiagnoses even at the height of the epidemic), (2) the striking incidence of hepatic involvement, and (3) the acceptable therapeutic response to intravenous (IV) ampicillin sodium.…”

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confidence: 99%

Typhoid fever. An epidemic with remarkably few clinical signs and symptoms

Klotz

Jorgensen

Buckwold

et al. 1984

Archives of Internal Medicine

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A major common-source, foodborne epidemic of typhoid fever occurred in San Antonio, Tex, in the fall of 1981, involving 80 verified cases. We summarize the clinical course of our 34 patients who had a nonspecific symptom complex that included at the initial examination fever (32 patients, 93%), headache (19 patients, 57%), diarrhea (11 patients, 33%), and anorexia (ten patients, 30%). The most common initial diagnoses were urinary tract and upper respiratory tract infections. The subsequent isolation of Salmonella typhi from blood cultures was usually unexpected. Physical findings were different from two previous series originating in the United States. Hepatomegaly was noted in only 7% (two patients), splenomegaly was noted in 13% (four patients), and rose spots were noted in 5% (two patients) of the patients. Liver function test results, however, were abnormal in 32 (95%) of the 34 patients (mean SGOT, 155 IU/mL). Typhoid fever, as seen in this outbreak, was notable for its nonspecific and mild manifestation and uniformly favorable outcome.

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Management of Typhoid Fever and Its Complications

Cited by 64 publications

References 20 publications

Oral ciprofloxacin treatment for Salmonella typhimurium infection of normal and immunocompromised mice

Oral ciprofloxacin treatment for Salmonella typhimurium infection of normal and immunocompromised mice

Typhoid Perforation of the Intestine

Typhoid fever. An epidemic with remarkably few clinical signs and symptoms

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