Management of trophoblastic tumors : review of evidence, current practice, and future directions

Deleuze, Antoine; Massard, Christophe; Du, Fanny Le; You, Benoît; Lefeuvre-Plesse, Claudia; Bolze, Pierre‐Adrien; Rouge, Thibault De La Motte

doi:10.1080/14737140.2023.2215438

Cited by 3 publications

(3 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This appears to be a promising way of avoiding combination of chemotherapy and its effects on the quality of life of young patients. Their efficacy has already been demonstrated in multidrug-resistant cases, but their role at an early stage of treatment is emerging ( 20 – 31 ).…”

Section: Discussionmentioning

confidence: 99%

“…and they showed a complete response (CR) of 75% (3/4 patients). The literature describes only case reports and series concerning the use of immunotherapy in these situations ( Table 2 ) ( 20 – 29 ). More recently Braga et al.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, our patient’s hCG level continued to rise, from 33.000 to 115.212 IU/L in 3 weeks, indicating resistance to treatment as defined in this protocol (> 20% increase in hCG level sustained over 3 weeks or plateau with < 10% decrease over 3–4 weeks) ( 31 ). The mechanisms of resistance to immunotherapy are not yet well understood, and although its use looks promising in the treatment of GTN, further work is needed to assess which patients would benefit most ( 20 , 23 , 26 ). There is currently only one clinical trial investigating on the use of ICI in the management of GTN.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Case report: Multidrug resistant gestational trophoblastic neoplasia: focus on failure of immunotherapy and success of high-dose chemotherapy

Enuset,

Duck,

Petre

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

Gestational trophoblastic neoplasia (GTN) is extremely rare, but has a very good prognosis, with a cure rate close to 100%, for low-risk diseases. This article describes the case of a healthy 28-year-old nulliparous patient with GTN resistant to multiple lines of treatment. The era of immunotherapy is revolutionizing oncology, having already proved its worth in the treatment of many cancers. This article will have a specific focus on the emerging role of immunotherapy in the treatment of GTN. Unfortunately, the use of an immune checkpoint inhibitor (ICI) failed in our case, emphasizing on the necessity to clearly define the future role of immune therapy in GTN. Finally, given the rapid progression of the disease after hysterectomy, induction with Paclitaxel- Ifosfamide and then intensification with high-dose Carboplatin and Etoposide with peripheral blood stem cell support was given as a rescue therapy with still curative intent.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Case report: Multidrug resistant gestational trophoblastic neoplasia: focus on failure of immunotherapy and success of high-dose chemotherapy

Enuset,

Duck,

Petre

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

show abstract

Actively Targeted Nanomedicines: A New Perspective for the Treatment of Pregnancy-Related Diseases

Yang,

Wang

2024

Reprod. Sci.

View full text Add to dashboard Cite

Intracardiac metastasis of gestational choriocarcinoma: a case report and literature review

Gu,

Zheng,

Xue

et al. 2024

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

Introduction Gestational trophoblastic neoplasia (GTN) with intracardiac metastasis is rare, and here we reported a patient with intracardiac metastasis of high-risk and refractory gestational choriocarcinoma and reviewed relevant literatures. Case presentation A 37-year-old woman presented with vaginal bleeding and high level of β-human chorionic gonadotropin (β-hCG) at 199,060 (mIU/mL). It was clinically diagnosed with gestational choriocarcinoma. The patient initially received eight cycles of chemotherapy but unsatisfactory response was observed, and the level of β-hCG still ranged between 5000 and 10,000. Then there was found intracardiac masses in the right atrium (2.6*1.7 cm), anterior chordae tendineae of the tricuspid valve (1.4*0.7 cm) and the right ventricle (4.1*2.9 cm) by ultrasonic cardiogram (UCG). PET/CT highly suspected the intracardiac metastasis of choriocarcinoma (SUVmax = 9.3) and no disease was found in the lung and pelvis. The patient undertook complete intracardiac masses resection. The pathology confirmed the intracardiac metastasis of disease. After a week of operation, the UCG found a 5.4*4.2 cm mass in the right atrium again. Considering the poor prognosis, the patient received palliative care and eventually died of disease progression. Conclusion Intracardiac metastasis of GTN is an aggressive sign of disease. Patients can benefit from chemotherapy and surgery. Future investigation of PD-1 immunotherapy combines with chemotherapy are expected to improve the prognosis in this group of patients.

show abstract

Management of trophoblastic tumors : review of evidence, current practice, and future directions

Cited by 3 publications

References 90 publications

Case report: Multidrug resistant gestational trophoblastic neoplasia: focus on failure of immunotherapy and success of high-dose chemotherapy

Case report: Multidrug resistant gestational trophoblastic neoplasia: focus on failure of immunotherapy and success of high-dose chemotherapy

Actively Targeted Nanomedicines: A New Perspective for the Treatment of Pregnancy-Related Diseases

Intracardiac metastasis of gestational choriocarcinoma: a case report and literature review

Contact Info

Product

Resources

About