Management of triple-negative breast cancer by natural compounds through different mechanistic pathways
Mohammed Kaleem,
Mandar Thool,
Nitin G. Dumore
et al.
Abstract:Triple-negative breast cancer (TNBC) is the most severe form of breast cancer, characterized by the loss of estrogen, progesterone, and human epidermal growth factor receptors. It is caused by various genetic and epigenetic factors, resulting in poor prognosis. Epigenetic changes, such as DNA methylation and histone modification, are the leading mechanisms responsible for TNBC progression and metastasis. This review comprehensively covers the various subtypes of TNBC and their epigenetic causes. In addition, t… Show more
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