Management of time-sensitive chemicals (II): Their identification, chemistry and management

Bio-oxygenates and the peroxide number: a safety issue alert

“…The formation of organic peroxides is one of the most dangerous transformations of organic compounds under air that can cause accidents during production, storage, transportation and use. [8][9][10][11] In addition, the formation of peroxides is not just a safety issue; they can lead to the initiation of various chemical reactions and thus the formation of impurities that could also alter product performance. Structurally, organic peroxides are derivatives of H 2 O 2 having one or both hydrogen atoms replaced by an organic moiety.…”

Chemical storage: Myths vs. reality

“…Some chemicals can generate additional hazards such as the formation of explosive peroxides (e.g., ethers) or toxic gases (e.g., chloroform), while others develop explosion from the evaporation of water (e.g., picric acid) or the generation of gases (e.g., anhydrous HF). 18 These chemicals must be identified and properly managed.…”

“…Step 5: Develop Time-Sensitive Chemical Storage Program A time-sensitive chemical storage program according to Bailey et al 18 should be developed. Elements of this program would include: (a) identification of time-sensitive chemicals, (b) tracking, (c) defining proper storage conditions, (d) determine inspection periods, (e) define when time-sensitive chemicals become ''unsafe'', and (f) managing ''unsafe'' time-sensitive chemicals.…”

Energy‐Efficient Synthesis of Haloquinazolines and Their Suzuki Cross‐Coupling Reactions in Propylene Carbonate

“…As a practical example, dimethoxyethane (DME) degraded into significant amount of peroxides (10 ppm) after several weeks and around 100 ppm after 2 years. [27] Obviously, to perform Suzuki reaction at high temperature is dangerous. Therefore, a time and energy consuming purification via distillation is used in order to carry out the reaction safely in this particular solvent.…”

“…Considering solvents, they should have relatively high volatility and low boiling point. As a practical example, dimethoxyethane (DME) degraded into significant amount of peroxides (10 ppm) after several weeks and around 100 ppm after 2 years [27] . Obviously, to perform Suzuki reaction at high temperature is dangerous.…”