Management of the Pressure Injury Patient with Osteomyelitis: An Algorithm

Nicksic, Peter J.; Sasor, Sarah E.; Tholpady, Sunil S.; Wooden, William A.; Gutwein, Luke G.

doi:10.1016/j.jamcollsurg.2017.08.017

Cited by 4 publications

(4 citation statements)

References 34 publications

(28 reference statements)

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“…The consequences of HAPI range from skin redness to full skin and tissue loss, exposing tendons and bones . If a person's injury advances, they face the prospect of osteomyelitis and sepsis . Issues such as pain, immobility, lack of independence, wound exudate, and odour impact patient's self‐image and emotional state, influence a person's quality of life …”

Section: Introductionmentioning

confidence: 99%

Pressure injury data in Australian acute care settings: A comparison of three data sets

Team

Tuck

Reeves

et al. 2020

International Wound Journal

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Hospital‐acquired pressure injuries (HAPIs) represent a serious clinical and economic problem. The cost of treating HAPIs in Australian public hospitals was recently reported at AUS$983 million per annum. There are three main sources of data for documenting pressure injury (PI) occurrence in Australian hospitals: incident reporting, medical record coded data, and real‐time surveys of pressure injury. PI data reported at hospital level and to external agencies using these three different sources are variable. This reporting issue leads to inaccurate data interpretation and hinders improvement in accuracy of PI identification and PI prevention. This study involved a comparison of the three different data sources in selected Australian hospitals, to improve the accuracy and comparability of data. Findings from this study provide benchmark areas for improvement in PI documenting and reporting. Better understanding the agreement between the three data sets could lead to a more efficient and effective sharing of data sources.

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Section: Introductionmentioning

confidence: 99%

Pressure injury data in Australian acute care settings: A comparison of three data sets

Team

Tuck

Reeves

et al. 2020

International Wound Journal

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“…Coronary artery bypass surgery complicated by deep sternal wound infection frequently involves osteomyelitis of the sternal bone [ 22 ]. Elderly and paraplegic patients are at higher risk of developing deep tissue pressure injuries (i.e., pressure ulcers) that are frequently complicated by osteomyelitis [ 23 , 24 ]. As confirmed by our findings of the limited inhibition effect of 1MIC antibiotic levels, the efficacy of the traditional intravenous and oral antibiotic administration is often limited in these conditions due to the relatively low antibiotic concentrations that can be attained at the infection site.…”

Section: Discussionmentioning

confidence: 99%

In-vitro model for bacterial growth inhibition of compartmentalized infection treated by an ultra-high concentration of antibiotics

Topaz

Athamna

Ashkenazi³

et al. 2021

PLoS ONE

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Background Pseudomonas aeruginosa (P. aeruginosa), Escherichia coli (E. coli), and Staphylococcus aureus (S. aureus) are common pathogens encountered in infected cardiovascular-implantable electronic device (CIED). Continuous, in-situ targeted, ultra-high concentration antibiotic (CITA) treatment is a novel antibiotic treatment approach for localized infections. CITA provides sufficient local antibiotic concentrations to heavily infected cavities while avoiding systemic toxicity. Aim In-vitro confirmation of the efficacy of the CITA treatment approach in simulated compartmentalized infections. Materials and methods A rapid automated bacterial culture analyzing system) Uro4 HB&L™ (was applied to compare the efficacy of selected antibiotics at a standard minimal inhibitory concentration (1MIC), 4MIC, and CITA at 103MIC, for growth inhibition of high bacterial loads (106 colony-forming-units/ml) of ATCC strains of P. aeruginosa, E. coli, and S. aureus. Results The addition of gentamicin and amikacin at 1MIC concentrations only temporarily inhibited the exponential growth of E. coli and P. aeruginosa. 4MIC level extended the delay of exponential bacterial growth. Increasing concentrations of vancomycin similarly temporarily delayed S. aureus growth. All tested antibiotics at CITA of 103MIC totally inhibited the exponential growth of the tested bacteria through 72 hours of exposure. (P<0.001). Conclusion In this in-vitro model, CITA at 103MIC effectively inhibited exponential bacterial growth of high loads of P. aeruginosa, E. coli, and S. aureus. This model offers preliminary laboratory support for the benefit of the in-situ antibiotic treatment, providing ultra-high concentrations directly at the compartmentalized infection site, not achievable by the conventional intravenous and oral routes.

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“…A pressure ulcer (PU) is a localized injury on the bony prominence caused by pressure and shearing[ 1 2 ] Risk factors for PUs include immobility, malnutrition, incontinence, aging, and chronic diseases. [ 3 4 ] Findings indicated that the prevalence and incidence of these wounds are various in different countries. [ 4 ] Its prevalence was reported to average 10.8% in Europe and 22%–44% in the intensive care unit (ICU) of the United States (US) hospitals.…”

Section: Introductionmentioning

confidence: 99%

Comparative evaluation of the effect of aloe vera gel, olive oil, and compound aloe vera gel-olive oil on prevention of pressure ulcer: A randomized controlled trial

Fallahi¹,

Soroush²,

Sadeghi³

et al. 2022

Adv Biomed Res

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Management of the Pressure Injury Patient with Osteomyelitis: An Algorithm

Cited by 4 publications

References 34 publications

Pressure injury data in Australian acute care settings: A comparison of three data sets

Pressure injury data in Australian acute care settings: A comparison of three data sets

In-vitro model for bacterial growth inhibition of compartmentalized infection treated by an ultra-high concentration of antibiotics

Comparative evaluation of the effect of aloe vera gel, olive oil, and compound aloe vera gel-olive oil on prevention of pressure ulcer: A randomized controlled trial

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