Management of the nephrotic syndrome.

Arneil, Gavin C.

doi:10.1136/adc.43.228.257

Cited by 7 publications

(8 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The results confirm the earlier reports on relapse rates following a prolonged initial steroid treatment [4,12] as well as a recent report [16] in which it was shown that a long-term tapering regimen with a 4 weeks continuous prednisone therapy followed by a 6 month alternate day treatment was more effective than a standard therapy of the initial attack. It remains however unclear whether the benefitial effect of a longer prednisone regimen in these studies was due to the increased cumulative steroid dosage or to the longer duration of immunosuppression during the extended prednisone therapy.…”

Section: Discussionsupporting

confidence: 93%

Long versus standard prednisone therapy for initial treatment of idiopathic nephrotic syndrome in children

1993

View full text Add to dashboard Cite

Two regimens of steroid treatment for the initial attack of idiopathic nephrotic syndrome (NS) in children were compared in a controlled prospective multi-centre study. Long prednisone therapy consisted of 60 mg/m2 per 24 h for 6 weeks, followed by alternate day 40 mg/m2 per 48 h for 6 weeks. The standard prednisone therapy was 60 mg/m2 per 24 h for 4 weeks, followed by 40 mg/m2 per 48 h for 4 weeks. A total of 71 children with an initial attack of idiopathic NS were allocated at random to the two groups. The cumulative rate of patients with sustained remissions after 2 years was significantly higher after the long course than after the standard treatment (49% vs 19%, P = 0.0079). The mean relapse rate per patient at intervals of 3, 6 and 12 months was lower in the long-course prednisone group than in the standard prednisone group, and the proportion of children with frequent relapses during any subsequent 6 months period was lower in the long-course group than in the standard group (29% vs 57%, P = 0.03). Mild side-effects of corticosteroid therapy were observed more frequently after long-course prednisone treatment. It is concluded that long-course prednisone therapy of the initial attack of steroid responsive NS is preferable to the standard regimen because it reduces the rate of subsequent relapses without increasing the risk for severe steroidal side-effects.

show abstract

Section: Discussionsupporting

confidence: 93%

Long versus standard prednisone therapy for initial treatment of idiopathic nephrotic syndrome in children

1993

View full text Add to dashboard Cite

show abstract

“…This discrepancy may be related to the steroid regimen used. A significant number of the patients included by Yap were treated by the 40-day drug course proposed by Arneil in 1968 [16]. This regimen reduces the steroid dosage after 10 days irrespective of the response on proteinuria, thereby increasing the risk of an insufficient steroid concentration and, consequently, prolongation of the time to achieve remission.…”

Section: Discussionmentioning

confidence: 99%

Early age at debut is a predictor of steroid-dependent and frequent relapsing nephrotic syndrome

Andersen

Thrane

Noergaard³

et al. 2010

Pediatr Nephrol

View full text Add to dashboard Cite

The purpose of this study was to identify characteristics of patients with steroid-sensitive nephrotic syndrome (SSNS) that point to a high risk of frequent relapsing (FR) or steroid-dependent (SD) SSNS. A retrospective analysis of 54 consecutive patients with SSNS was performed. In this cohort, the incidence of idiopathic NS was 1.9/100,000, age at debut was 5.5 years, and the mean follow-up was 4.0 years. A total of 56% (30/54) of our patients were classified with FR/SD SSNS. FR/SD patients were significantly younger at debut than non-FR/SD patients (3.5 vs. 8.5 years, respectively; p < 0.002). Males were overrepresented in the FR/SD group (69 vs. 38%; p = 0.03). No differences were found in terms of haematuria, hypoalbuminaemia, or days to achieve remission. In total, 31 and 23 patients were on a 6 + 6-week (pred-long) and 4 + 4-week (pred-short) steroid treatment regimen, respectively. There was a reduction in the number of FR/SD patients in the pred-long group relative to the pred-short group (38 vs. 80%, respectively). In the pred-long group, the 12 FR/SD patients were younger than the 19 non-FR/SD patients (4.4 +/- 3.1 vs. 8.4 +/- 4.1 years; p<0.005). Low age at debut and male gender was associated with a high risk of SD/FR in this unselected series of SSNS patients despite the prolongation of the steroid course at debut of SSNS.

show abstract

“…Другой терапии на тот момент не было, хотя пони-мали, что ртуть сама может способствовать развитию отеков [33]. О характере исходов нефротического синдрома впервые написал G. Arneil [34]. Результаты его исследований в эру без современных диуретиков и антибактериальных средств были нами дополнены позже, когда эти средства появились [1].…”

Section: синдромологическая терапия нефротического син-дромаunclassified

“…Глюкокортикоиды служат основными препаратами при лечении пациентов с нефротическим синдро-мом. Об этом, проанализировав характер течения нефротического синдрома на протяжении десятиле-тий, сообщил G. Arneil (1976) [34] (табл. 5).…”

Section: патогенетическая терапияunclassified

Nephrotic Syndrome: Past, Present and Future

Ignatova¹,

Длин²

2017

Ross. vestn. perinatol. pediatr.

View full text Add to dashboard Cite

Management of the nephrotic syndrome.

Cited by 7 publications

References 20 publications

Long versus standard prednisone therapy for initial treatment of idiopathic nephrotic syndrome in children

Long versus standard prednisone therapy for initial treatment of idiopathic nephrotic syndrome in children

Early age at debut is a predictor of steroid-dependent and frequent relapsing nephrotic syndrome

Nephrotic Syndrome: Past, Present and Future

Contact Info

Product

Resources

About