“…In their opinion, hypertrophic nonunion tissue can serve as a reservoir of mesenchymal cells, which can be induced to stimulate union, without the need for directly treating the nonunion site, if abundant vascularity and stabilisation of the fracture site can be ensured [1]. The hypertrophic changes at the nonunion site reflect the intrinsic callus-forming ability and biologic healing potential of the tissue [5,14,15]. In such cases, the mechanical environment should be managed such that it is conducive to callus formation, remodeling, and consolidation.…”