Management of Stage II testicular seminoma over a period of 40 years

Retroperitoneal Lymph Node Dissection as First-Line Treatment of Node-Positive Seminoma

“…Although representing a small sample size, the data compare favorably with the recurrence rates seen after EBRT and CT (Table 2). 11,12,17,18,[20][21][22][23][24][25][26][27] Most studies have examined the recurrence rate after EBRT, which has been 0% to 17%. The outcomes after cisplatin-based CT, although also of smaller sample sizes, have been favorable.…”

Radiotherapy for Stage IIA seminoma: The Northern Israel Oncology Center Experience, 1971–2010

“…9,10 A German Prospective Multicenter Clinical Trial 4 which enrolled 30 participating centers and 66 Stage IIA patients found that 30 Gy yielded 100% in-field tumor control and compared favorably with total doses (30-35 Gy, including boost) of previous reports in the literature 2,3,6 and also with the current literature. 1,11 It seems that only prospective studies, like the German Study, could reveal the most appropriate dose/schedule for IIA patients.…”

“…Large studies have been done with the superior border at the top of the T11 vertebral body and even at T9/T10. 1,10 Whole pelvis should be considered only if lymphatic disruptions occur such as following pelvic operation, inguinal hernia repair or surgery due to mal-or undescended testis. 4,12 Prophylactic mediastinal and left supra-clavicular irradiation has been totally omitted due to its non-contribution to survival and increased rate of secondary malignancies, such as lung and thyroid cancer, and of cardiovascular diseases.…”

“…1 Due to the high radiosensitivity of seminoma, radiotherapy has become the mainstay of treatment in limited nodal involvement. 1,2 Cause-specific survival usually exceeds 90% and, in recent years, has been approaching 100%. Relapse rates reported in the literature vary according to stage and treatment modality with 11%, 19%, and 39% in Stage IIA, IIB, and IIC, respectively.…”

“…Relapse rates reported in the literature vary according to stage and treatment modality with 11%, 19%, and 39% in Stage IIA, IIB, and IIC, respectively. 1 Stage IIB (2-5 cm in size lymph nodes) can be treated successfully with platinum-based chemotherapy or high-dose radiotherapy to high-volume fields with chemotherapy held for relapse. In this retrospective study, we review our clinic's experience in radiotherapy treatment, outcome and toxicity in 24 Stage IIA post-orchiectomy seminoma patients over a period of 39 years.…”