Management of squamous cell vulvar cancer: A review

Abstract

Squamous cell vulvar cancer is a rare gynecologic malignancy. Standard treatment for early stage disease consists of wide radical excision of the primary tumor with inguinal-femoral lymphadenectomy or sentinel lymph node mapping/biopsy. Because of the general paucity of patients with advanced vulvar cancer, there is no standard therapy for advanced disease and therefore treatment should be individualized. Intergroup trials are needed to clarify the value of chemoradiation, neoadjuvant chemotherapy and targeted therapy in patients with advanced squamous cell cancer of the vulva to identify modalities with the best therapeutic index and lowest morbidity.

Vulvar cancer is not a disease of the elderly: Treatment and outcome at a tertiary referral centre in South Africa

“…This is in keeping with other reported studies, where recurrence occurred in approximately one-third of patients. [22] Recurrence indicated a poor prognosis, as 26 of the 41 patients died. The 9 patients with complete response after recurrence all had the recurrent tumour removed surgically, 7 from the vulva and 2 from the groin.…”

Recommendations of the Polish Gynecological Oncology Society for the diagnosis andtreatment of vulvar cancer

“…TREATMENT (2,3,6) The treatment of vulvar cancer involves surgery, radiation therapy, chemoradiation and chemotherapy. Contribution of different treatment modalities in relation to the FIGO stage is shown in Fig.…”

Vulvar cancer: initial management and systematic review of literature on currently applied treatment approaches

“…Cutaneous or myocutaneous flaps are used to close the dead space created by surgery and bring new vascularity to the area as opposed to superficial skin grafting. Various methods have been proposed: split thickness skin grafting (skin graft harvested from inner thighs or buttocks), rhomboid transposition flaps, V-Y advancement flap, (advancement of the flap from pubo-labial, gluteal or medial thigh region) and myocutaneous flaps (flaps that include a segment of muscle tissue such as the short gracilis or bulbocavernosus muscle) (Deppe et al 2014). The details of these techniques are beyond the scope of the current review, however are well described in Hockel and Dornhofer (2008).…”