Dear Editor,We report a case of disseminated Staphylococcus intermedius infection causing multiple spleen abscesses with consecutive splenectomy in a patient with acute lymphoblastic leukemia.A 49-year-old female patient underwent induction chemotherapy in accordance with the Germany Multicentre Study Group (GMALL) 08/2013 protocol for a precursor B-cell acute lymphoblastic leukemia (ALL). Fever episodes occurred during neutropenia, accompanied by intermittent left flank pain and increased inflammation parameters with a maximum C-reactive protein of 368.9 mg/l (normal range, < 5.0 mg/l). Extensive microbiological diagnostics including multiple blood and urine cultures did not reveal any relevant pathogens. Despite broad-spectrum antimicrobial therapy including a combination therapy of meropenem, linezolid, and fosfomycin, later ceftazidime, tigecycline, and liposomal amphotericin B, no improvement of clinical and laboratory parameters was achieved. Abdominal computed