Management of Skin Abscesses in the Era of Methicillin-Resistant <i>Staphylococcus aureus</i>

Singer, Adam J.; Talan, David A.

doi:10.1056/nejmra1212788

Cited by 142 publications

(109 citation statements)

References 45 publications

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“…vaccine | Staphylococcus aureus | skin | Th22 | Th17 T he bacterium Staphylococcus aureus is the leading cause of skin and skin structure infections (SSSIs), including cellulitis, furunculosis, and folliculitis (1)(2)(3)(4), and a common etiologic agent of impetigo (5), erysipelas (6), and superinfection in atopic dermatitis (7). This bacterium is a significant cause of surgical or traumatic wound infections (8,9), as well as decuibitus and diabetic skin lesions (10).…”

mentioning

confidence: 99%

Mechanisms of NDV-3 vaccine efficacy in MRSA skin versus invasive infection

Yeaman

Filler

Chaili

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Significance Staphylococcus aureus is an opportunistic pathogen of the normal human flora. It is among the most frequent causes of cutaneous abscesses, leading to life-threatening invasive infection. Incomplete understanding of host defenses against S. aureus skin or invasive infection has hindered development of effective vaccines to address these issues. NDV-3 is a unique cross-kingdom vaccine targeting S. aureus and Candida albicans . The present studies offer important new evidence: ( i ) NDV-3 protects against methicillin-resistant S. aureus skin and skin structure infection largely through IL-22– and IL-17A–mediated host defense peptide and neutrophil induction, ( ii ) vaccine-mediated IL-22 and IL-17A play distinct roles in protection against cutaneous versus invasive infection, and ( iii ) NDV-3 vaccine efficacy in this model involves a coordinated induction of innate and adaptive immunity.

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mentioning

confidence: 99%

Mechanisms of NDV-3 vaccine efficacy in MRSA skin versus invasive infection

Yeaman

Filler

Chaili

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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“…MEDICINA purulentas no fue empleado sino en uno de los casos, lo cual, según otros estudios, puede reducir la tasa de fracaso al tratamiento (31,32).…”

Section: Cuadro 1 Características Sociodemográficas Y Clínicasunclassified

Prescripción de antibióticos en infecciones de piel y tejidos blandos en una institución de primer nivel

Machado‐Alba¹,

Castrillón-Spitia

Palacio³

et al. 2018

CES Med.

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“…Los SAMR-CA causan infecciones severas, incluyendo neumonía necrotizante, fascitis, púrpura fulminas y sepsis severa. Tiene una virulencia mayor que las cepas de SAMR-HA y que los Staphylococcus aureus meticilino (2) sensibles, hecho aún no bien comprendido .…”

Section: Materiales Y Métodosunclassified