Management of sinonasal chondrosarcoma: a systematic review of 161 patients

Khan, Muhammad Zia; Husain, Qasim; Kanumuri, Vivek V.; Boghani, Zain; Patel, Chirag; Liu, James K.; Eloy, Jean Anderson

doi:10.1002/alr.21162

Cited by 46 publications

(68 citation statements)

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“…This is in agreement with the current literature on chondrosarcoma of the head and neck, which emphasizes the importance of negative margins and grade on survival and treatment outcomes [6]. …”

Section: Discussionsupporting

confidence: 92%

Head and neck sarcomas: the UCLA experience

Tajudeen¹,

Fuller

Lai

et al. 2014

American Journal of Otolaryngology

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Purpose To profile the clinical presentation, subtype distribution, and treatment results of sarcomas of the head and neck at a single tertiary academic center over an 11-year period. Materials and Methods A retrospective review was performed by examining the records and reviewing the pathology of 186 patients with head and neck sarcomas treated at UCLA Medical Center from 2000 to 2011. Results The mean age of the study population was 49 +/− 22 years. 58% of the patients were male and 42% were female. Median duration of follow-up for the entire group was 18.5 months. The most common presenting symptom was a mass lesion in 59.9% of patients. The nasal cavity/sinus was the most common presenting site seen in 22% of patients. Solitary fibrous tumor/hemangiopericytoma was the most common subtype. 15% of patients had evidence of prior radiation exposure. 26.3% of tumors were greater than 5cm and 35.5% were high-grade. Margins were positive in 31.2% of patients. Lymph node metastasis was rare at 6.5%. Perineural invasion was identified in 6.5%. Among all subtypes, 5-yr recurrence-free survival and overall survival were 50% and 49%, respectively. Multivariate analysis demonstrated that grade and margin status were predictors of recurrence-free survival while grade and age affected overall survival. Conclusions Head and neck sarcomas are a rare entity frequently presenting as a mass lesion. In our series, lesions tended to be high-grade with a significant portion of surgical specimens having positive margins. Grade and margin status were the most important predictors of survival.

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Section: Discussionsupporting

confidence: 92%

Head and neck sarcomas: the UCLA experience

Tajudeen¹,

Fuller

Lai

et al. 2014

American Journal of Otolaryngology

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“…No conclusions on the efficacy of systemic therapy could be made [78] and the role of systemic treatment in the management of this disease seems to be limited.…”

Section: Sarcomamentioning

confidence: 99%

The role of systemic therapy in the management of sinonasal cancer: A critical review

Bossi

Saba

Vermorken

et al. 2015

Cancer Treatment Reviews

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“…The literature regarding surgical management of chondrosarcomas is limited to small case series with a systematic review bringing together only 161 cases (Khan et al, 2013). There is a paucity of consensus regarding the most efficacious surgical approaches to chondrosarcomas located in the clival region.…”

Section: Resultsmentioning

confidence: 99%

“…The use of adjuvant radiation therapy combination with surgery is increasingly utilised, reportedly employed in sinonasal chrondrosarcomas diagnosed after 1990 (Khan et al, 2013). there is a lack of conclusive statistical evidence given the rarity of these tumours, There are various radiotherapy modalities available including fractionated photon radiotherapy, proton therapy, particle therapy with ions and stereotactic radiosurgery.…”

Section: Adjuvant Radiotherapymentioning

confidence: 99%

“…Whilst this is consistent with previous studies (Oghalai et al, 2005, Colli and Al-Mefty, 2001), the largest study of intracranial chondrosarcoma, by Rosenberg et al, 1999, demonstrates a 5-year survival of 99% when surgery is combined with adjuvant radiotherapy (Rosenberg et al, 1999). Intracranial Chondrosarcomas arise predominantly at the base of the skull with the most common location being the clivus (32%) followed by the temporo-occipital junction (Bloch et al, 2009, Khan et al, 2013. The predilection for the skull base is thought to be related to the difference in bone development as endochondral ossification predominates in the basilar structures of the skull compared to intramembranous ossification in other areas (Bloch and Parsa, 2013).…”

Section: Introductionmentioning

confidence: 99%

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