Management of severe in-patient hyponatraemia: An audit in two teaching hospitals in Yorkshire, UK

Narayanan, Deepa; Mbagaya, Wycliffe; Aye, Mo; Barth, Julian H.

doi:10.3109/00365513.2014.926563

Cited by 9 publications

(14 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, hepcidin levels determined by this assay correlated significantly with hepcidin-25 determined by mass spectrometry in the study by Dahlfors and co-workers [ 27 ]. Due to cross-reactivity with hepcidin-20 and -22, the level of hepcidin was approximately 30% higher when hepcidin was analysed using the ELISA assay compared to the level using hepcidin-25 specific mass spectrometry [ 27 ]. Although not specific for hepcidin-25, the mean hepcidin level was significantly lower in subjects with ID compared to healthy controls using this ELISA assay [ 27 ].…”

Section: Discussionmentioning

confidence: 76%

“…In contrast to the ELISA developed by Butterfield and co-workers. [ 26 ], the competitive ELISA assay used in this study is not specific for hepcidin-25 [ 27 ], but it cross-reacts with hepcidin-20 and -22. However, hepcidin levels determined by this assay correlated significantly with hepcidin-25 determined by mass spectrometry in the study by Dahlfors and co-workers [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…[ 26 ], the competitive ELISA assay used in this study is not specific for hepcidin-25 [ 27 ], but it cross-reacts with hepcidin-20 and -22. However, hepcidin levels determined by this assay correlated significantly with hepcidin-25 determined by mass spectrometry in the study by Dahlfors and co-workers [ 27 ]. Due to cross-reactivity with hepcidin-20 and -22, the level of hepcidin was approximately 30% higher when hepcidin was analysed using the ELISA assay compared to the level using hepcidin-25 specific mass spectrometry [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of a competitive hepcidin ELISA assay in the differential diagnosis of iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients

Karlsson

2017

J Inflamm

View full text Add to dashboard Cite

In this study, a competitive hepcidin ELISA assay was evaluated for its ability to differentiate between iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients, using the absence of stainable bone marrow iron as the diagnostic criterion for iron deficiency. In addition, correlation coefficients for hepcidin versus C-reactive protein, ferritin and interleukin-6 were determined. The optimal cut-off for hepcidin was 21 μg/L, corresponding to sensitivity and specificity of 100% and 67%, respectively, for iron deficiency. For ferritin, a sensitivity and specificity of 91% and 83%, respectively, correspond to an optimal cut-off of 87 μg/L. Receiver operating characteristics curve analysis revealed that ELISA analysis of hepcidin is not superior to ferritin in the diagnosis of iron deficiency in elderly anaemic patients with concurrent inflammation. Hepcidin shows a strong positive correlation with ferritin, and also correlates positively with C-reactive protein in this patient population.

show abstract

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of a competitive hepcidin ELISA assay in the differential diagnosis of iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients

Karlsson

2017

J Inflamm

View full text Add to dashboard Cite

show abstract

“…Previous studies have found that adrenal insufficiency is not always considered as a cause of hyponatraemia [6] , [7] . Analysis of data from our second gather is in keeping with this statement; we found that for patients with severe hyponatraemia, only 42% had a serum cortisol measurement within two weeks of the initial finding of hyponatraemia.…”

Section: Discussionmentioning

confidence: 98%

“…Clinical practice guidelines on hyponatraemia advise that primary or secondary adrenal insufficiency should always be considered as a potential cause of hyponatraemia [5] . Despite this advice to measure serum cortisol in hyponatraemic patients, recent audits suggest that this is infrequently done [6] , [7] . We have analysed a large dataset to investigate the frequency of cortisol requesting in patients with severe hyponatraemia, and to determine the relative frequency of adrenal insufficiency in this cohort.…”

Section: Introductionmentioning

confidence: 99%

An analysis of the relationship between serum cortisol and serum sodium in routine clinical patients

Mclaughlan

Barth

2017

Practical Laboratory Medicine

Self Cite

View full text Add to dashboard Cite

ObjectivesAdrenal insufficiency is an uncommon cause of hyponatraemia that should not be overlooked due to the severe consequences of an Addisonian crisis. Using the laboratory database of a large teaching hospital, we have explored the relationship between serum sodium and serum cortisol, and have estimated the frequency of hypoadrenalism in severely hyponatraemic patients.Design and methodsData were gathered over a 23 month period from the Laboratory Information Management System at the Leeds Teaching Hospitals NHS Trust for instances where serum sodium and cortisol had been measured on a single sample. Data were also gathered over the same time period for all patients with severe hyponatraemia (serum sodium ≤120 mmol/L) in order to determine the frequency of cortisol requesting and the incidence of adrenal insufficiency.ResultsAnalysis of the data (n=3268 patients) revealed a trend showing higher cortisol concentrations in patients who were severely hypo- or hypernatraemic. The median cortisol concentration for patients with sodium ≤110 mmol/L was 856 nmol/L, and there was a gradual decrease in cortisol over the sodium range ≤110–150 mmol/L (Rs =−0.323, p<0.0001). Patients with sodium ≥151 mmol/L had a median cortisol of 725 nmol/L. 42% of the 978 patients with serum sodium ≤120 mmol/L had serum cortisol measured within two weeks, of whom 1.7% were diagnosed with adrenal insufficiency.ConclusionsThis dataset shows rising cortisol in response to hypo- or hypernatraemia, in keeping with the stress response to illness. The data show that adrenal insufficiency is a rare cause of hyponatraemia which may be overlooked.

show abstract

Gold-silver core-shell nanoparticle–based impedimetric immunosensor for detection of iron homeostasis biomarker hepcidin

et al. 2020

View full text Add to dashboard Cite

Management of severe in-patient hyponatraemia: An audit in two teaching hospitals in Yorkshire, UK

Abstract: Severe hyponatraemia is associated with significant morbidity and mortality. Drug-induced hyponatraemia was the most common aetiology observed in our group of patients.

Cited by 9 publications

References 16 publications

Evaluation of a competitive hepcidin ELISA assay in the differential diagnosis of iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients

Evaluation of a competitive hepcidin ELISA assay in the differential diagnosis of iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients

An analysis of the relationship between serum cortisol and serum sodium in routine clinical patients

Gold-silver core-shell nanoparticle–based impedimetric immunosensor for detection of iron homeostasis biomarker hepcidin

Contact Info

Product

Resources

About