Management of Severe and Severe/Complicated <i>Clostridoides difficile</i> Infection Using Sequential Fecal Microbiota Transplant by Retention Enema

Rupawala, Abbas; Gachette, Darrel; Bakhit, Mena; Jimoh, Lanre; Kelly, Colleen R.

doi:10.1093/cid/ciab041

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…J o u r n a l P r e -p r o o f patients indicated less favourable results with 87% response at day 7, but 33% sustained cure at day 30, with one colectomy and two (of five) deaths attributable to CDI [216]. Although the level of evidence is very low, considering the high mortality associated with surgical therapy for CDI and the fact that some patients are too ill to be surgical candidates, the committee believes there is a place for FMT in patients with refractory severe complicated CDI for whom surgery is not feasible, providing that (1) surgical consultation is always sought, ( 2…”

Section: The Role Of Fmt In Severe-complicated Refractory CDImentioning

confidence: 96%

European Society of Clinical Microbiology and Infectious Diseases: 2021 update on the treatment guidance document for Clostridioides difficile infection in adults

Prehn

Reigadas

Vogelzang

et al. 2021

Clinical Microbiology and Infection

281

320

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: The Role Of Fmt In Severe-complicated Refractory CDImentioning

confidence: 96%

European Society of Clinical Microbiology and Infectious Diseases: 2021 update on the treatment guidance document for Clostridioides difficile infection in adults

Prehn

Reigadas

Vogelzang

et al. 2021

Clinical Microbiology and Infection

281

320

View full text Add to dashboard Cite

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“…It is important to instruct patients to resist the urge to defecate and retain the enema for as long as possible. Studies have also recommended that retention enemas may be a good adjunctive FMT treatment in addition to upper GI administration ( 186 ).…”

Section: Fecal Microbiota Transplant Delivery Methodsmentioning

confidence: 99%

Fecal microbiota transplantation in non-communicable diseases: Recent advances and protocols

et al. 2022

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Fecal microbiota transplant (FMT) is a therapeutic method that aims to restore normal gut microbial composition in recipients. Currently, FMT is approved in the USA to treat recurrent and refractory Clostridioides difficile infection and has been shown to have great efficacy. As such, significant research has been directed toward understanding the potential role of FMT in other conditions associated with gut microbiota dysbiosis such as obesity, type 2 diabetes mellitus, metabolic syndrome, neuropsychiatric disorders, inflammatory bowel disease, irritable bowel syndrome, decompensated cirrhosis, cancers and graft-versus-host disease. This review examines current updates and efficacy of FMT in treating conditions other than Clostridioides difficile infection. Further, protocols for administration of FMT are also discussed including storage of fecal samples in stool banks, inclusion/exclusion criteria for donors, fecal sample preparation and methods of treatment administration. Overall, understanding the mechanisms by which FMT can manipulate gut microbiota to provide therapeutic benefit as well as identifying potential adverse effects is an important step in clarifying its long-term safety and efficacy in treating multiple conditions in the future.

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The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridioides difficile infection and other potential indications: second edition of joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines

Mullish,

Merrick,

Quraishi

et al. 2024

Journal of Hospital Infection

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Management of Severe and Severe/Complicated Clostridoides difficile Infection Using Sequential Fecal Microbiota Transplant by Retention Enema

Cited by 4 publications

References 12 publications

European Society of Clinical Microbiology and Infectious Diseases: 2021 update on the treatment guidance document for Clostridioides difficile infection in adults

European Society of Clinical Microbiology and Infectious Diseases: 2021 update on the treatment guidance document for Clostridioides difficile infection in adults

Fecal microbiota transplantation in non-communicable diseases: Recent advances and protocols

The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridioides difficile infection and other potential indications: second edition of joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines

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