Management of Severe Acute Pancreatitis

Siregar, Gontar Alamsyah; Siregar, Ginanda Putra

doi:10.3889/oamjms.2019.720

Cited by 26 publications

(21 citation statements)

References 27 publications

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“…In the present study, we found that the changes in plasma mtDNA levels showed a statistical consistency with the APACHE II, SOFA, and Ranson scores. Previous studies have con rmed that the APACHE II and Ranson scores are useful tools to evaluate the severity and prognosis of SAP [23][24][25]. The calculated Pearson correlation coe cients showed that that the mtDNA level correlated positively with the APACHE II, SOFA, and Ranson scores, suggesting that the mtDNA concentration might represent a new marker to evaluate SAP.…”

Section: Discussionmentioning

confidence: 82%

Dynamic Changes in Plasma Mitochondrial DNA Concentration in Patients with Severe Acute Pancreatitis

Duan

Wang

Hua

et al. 2020

Preprint

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Background: The elevated plasma mitochondrial DNA (mtDNA) is associated with prognosis in patients with severe acute pancreatitis (SAP). However, it is not clear that the dynamic process of plasma mtDNA during the early stage of SAP and the correction between mtDNA and clinical features.Methods: Twenty-six eligible patients with SAP in the general intensive care unit of our institution were enrolled in this study. The mtDNA concentration were assessed at admission and on days 3, 5, and 7.Results: The mtDNA concentration of the patients with SAP was elevated at each time point compared with that in the healthy controls. The mtDNA levels increased rapidly, peaking on day 3 after admission, and began to decrease on day 5. The trend remained statistically consistent among the acute physiology and chronic health evaluation (APACHE II) score, the sequential organ failure assessment (SOFA) score, C-reactive protein (CRP) levels and mtDNA levels. Contrastingly, the changes were not statistically consistent among the procalcitonin (PCT), calciumion (Ca2+) and mtDNA concentrations. The mtDNA level correlated significantly with the APACHE II score, SOFA score, and Ranson score, but not with the CRP, PCT, and Ca2+ concentrations. Conclusions: The dynamic change of plasma mtDNA correlated significantly with SAP development. The elevated mtDNA levels could be used as a biomarker for the early stage of SAP.Trial registration: NCT: 04079777. Registered 4 September 2019 - Retrospectively registered, https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S00096E5&selectaction=Edit&uid=U0002O5I&ts=2&cx=-e6bci8

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Section: Discussionmentioning

confidence: 82%

Dynamic Changes in Plasma Mitochondrial DNA Concentration in Patients with Severe Acute Pancreatitis

Duan

Wang

Hua

et al. 2020

Preprint

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“…Inhibition of exocrine the pancreatic secretion with octreotide which is somatostatin or its synthetic analogue, has been extensively studied. Although many studies have reported the effect of exocrine secretion inhibition on the course of the disease (11,22,23), it has also been reported that it reduces complications in elective surgery (24) and positively affects (25). In consequence, the place of medical treatment in acute pancreatitis treatment is very limited.…”

Section: Discussionmentioning

confidence: 99%

The Place of Early Period ERCP in Acute Biliary Pancreatitis?

Aslan

Peker

Yıldırgan

2021

Konuralp Tıp Dergisi

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Objective: Acute pancreatitis;It can be defined as a clinical picture that occurs as a result of non_bacterial inflammation of the pancreas and may progress with pathological findings. For years, various studies have been conducted on the use of Endoscopic Retrograde Cholangiopancreotography and Endoscopic Sphincterotomy for therapeutic purpose in Acute Pancreatitis. For years, various studies have been conducted on the use of Endoscopic Retrograde Cholangiopancreotography and Endoscopic Sphincterotomy for therapeutic purpose in Acute Pancreatitis. In our study, we aimed to examine either the effectiveness of Endoscopic Retrograde Cholangiopancreotography and Endoscopic Sphincterotomy in patients with mild severity, and how the endoscopic procedure affects the course of the disease. Methods: In this study, patients with mild pancreatitis were selected among the patients who applied to the Department of General Surgery, of Atatürk University Faculty of Medicine and diagnosed with acute biliary pancreatitis (ABP). After the patients were separated according to the mild pancreatitis, early (within 72 hours) and late period, they were randomly selected to be performed Endoscopic Retrograde Cholangiopancreotography and Endoscopic Sphincterotomy. 59 patients were detected in this way. Results: Twelve (20.3%) of the patients included in our study were male, and 47 (79.7%) were female, and their ages were between 25-75 years (mean 64.3 years). Two groups were created in order to perform ERCP/ES in the early and late periods. All patients had acute onset abdominal pain and serum amylase levels have been ranging between (1012-7660 UI/L). Conclusions: In patients with mild acute biliary pancreatitis, there is no significant difference in the early (first 72 hours) ERCP/ES results compared to the results of patients with ERCP/ES in the late period.

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“…The low level of user accuracy and producer accuracy could be due to difficulty of position matching between imagery and field data such as image position shift with GPS causing deplacement of observed object location [30]. In addition, the number of sample variations in the field also affects the results of accuracy [4].…”

Section: Table 4 Accuracy Assesment Based On Landsat 8 Satellite Imamentioning

confidence: 99%

Classification of shallow water seabed profile based on Landsat 8 imagery and in-situ data. Case study in Gili Matra Island Lombok, Indonesia

et al. 2018

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Shallow water seabed profile has considerable potential resources so the availability of information which very important for coastal resources. The use of remote sensing techniques is considered to provide coastal information effective and efficient. This research aimed to determine the shallow water seabed profile based on Landsat 8 Imagery and its accuracy related to the in situ data. Methods of this research are satellite mage pre-processing, image classification, field survey, image classification, and accuracy assesment . Therefore, 6 classification of shallow water seabed profile, there are rubble (R), seagrass mixed sand (MIX -SG/SD), coral reefs mixed rubble (MIX-C/RB), rubble mixed dead coral (MIX-RB/DC), sand mixed rubble (MIX-SD/RB), and sand mixed seagrass (MIX-SD/SG), respectevely. The result of this classification has an accuracy value 80%.

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Management of Severe Acute Pancreatitis

Cited by 26 publications

References 27 publications

Dynamic Changes in Plasma Mitochondrial DNA Concentration in Patients with Severe Acute Pancreatitis

Dynamic Changes in Plasma Mitochondrial DNA Concentration in Patients with Severe Acute Pancreatitis

The Place of Early Period ERCP in Acute Biliary Pancreatitis?

Classification of shallow water seabed profile based on Landsat 8 imagery and in-situ data. Case study in Gili Matra Island Lombok, Indonesia

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