Management of rhino-orbital mucormycosis

Mohamed, Moustafa M.; Abdel-Motaleb, Hesham Y.; Mobarak, Fahmy A.

doi:10.15537/smj.2015.7.11859

Cited by 19 publications

(13 citation statements)

References 9 publications

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“…The samples were crushed in a mortar under sterile conditions and then homogenized. Afterwards, 5 g of each soil sample was suspended in 20 ml of sterile double-distilled water and shaken for 5 min to prepare a soil suspension [ 18 , 19 ]. Approximately 0.5 ml of the suspension was poured in the bottom of a Petri dish.…”

Section: Methodsmentioning

confidence: 99%

Identification of Mucorales isolates from soil using morphological and molecular methods

et al. 2016

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Background and Purpose:Soil is the main habitat of saprophytic and pathogenic fungi. Mucoromycotina constitutes a large group of soil fungi, with certain opportunistic members causing systemic infections in immunocompromised hosts. The majority of human and animal infections are caused by the members of the genera Rhizopus, Mucor, Rhizomucor, Lichtheimia (Absidia), Cunninghamella, and Mortierella. Accordingly, in the present study, we aimed to isolate and identify the main genera of the order Mucorales, using molecular assays and morphological features.Materials and Methods:In total, 340 soil samples were collected from seven public parks throughout the city and sidewalk gardens in 14 municipal districts in Isfahan, Iran. All the samples were cultured on the appropriate media, incubated at 27°C for 2- 4 days, and examined daily for visible fungal growth. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was applied and macroscopic, microscopic, and physiological characteristics were assessed to identify fungal colonies.Results:400 pure colonies, belonging to the orders Mucorales and Mortierellales, including the genera Lichtheimia, Rhizopus, Rhizomucor, Mucor, Cunninghamella, and Mortierella, were identified. The genus Rhizopus (35.5%) was the most frequent isolate, followed by Mucor (32.25%) and Rhizomucor (27.5%).Conclusion:The results emphasize the importance of opportunistic fungi in public areas and indicate the risk of exposure for immunocompromised individuals.

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Section: Methodsmentioning

confidence: 99%

Identification of Mucorales isolates from soil using morphological and molecular methods

et al. 2016

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“…Prompt diagnosis and effective treatment of the primary disease are extremely important for the future prognosis. The therapy should be based on wide excision of the necrotic tissue early in the course of the disease and the implementation of antifungal drugs [23]. Liposomal amphotericin B used intravenously is usually effective.…”

Section: Eye Socketmentioning

confidence: 99%

Mycotic Infections of the Eye

Słowik¹,

Biernat²,

Urbaniak-Kujda³

et al. 2015

Adv Clin Exp Med

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Fungal infections of the eye are an important cause of significant visual loss and blindness in some regions of the world, especially developing countries. Ocular mycoses remain a diagnostic and therapeutic challenge to the ophthalmologist. Corneal infection is the most frequent presentation, but the orbit, eyelids, lacrimal apparatus, conjunctiva, sclera and internal structures of the eye can also be affected. Candida spp., Fusarium spp. and Aspergillus spp. are the most frequently isolated organisms in fungal keratitis and in endophthalmitis. The difficulties posed by ocular mycoses are mainly related to establishing the clinical diagnosis, isolation of the fungal pathogen and effective local treatment, particularly in infections of the cornea. The critical issue in diagnosing fungal infection of the eye is microbiological identification of the etiologic agent in clinical samples. Early diagnosis and prompt treatment allow serious complications, including blindness, to be avoided. Local, systemic and even surgical treatment is applied in the therapy.

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“…However, despite the advancement of therapy methods, the mortality rate of rhino-orbito-cerebral mucormycosis is still as high as 20 to 50 %. 10,14 In this case, cavernous sinus syndrome occurred…”

Section: Casementioning

confidence: 71%

A Case Of Cavernous Sinus Syndrome and Mutifocal Cerebral Infarction Related To Mucormycosis Of Sphenoid Sinus

Jeon

Kim

et al. 2018

KMJ

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A 54-year-old man, suffering from severe headache and ophthalmoplegia after undergoing endoscopic sinus surgery was referred to a tertiary hospital. Computed tomography (CT) revealed soft tissue density lesions in the left sphenoid sinus. The internal carotid artery was shown to be occluded in brain magnetic resonance imaging (MRI) scans without any other cerebral lesion. Endoscopic view of left nasal cavity shows whitish hyphae in the ethmoid and the sphenoid sinuses. We diagnosed him with cavernous sinus syndrome caused by mucormycosis and conducted endoscopic sinus surgery to remove remaining lesions and decompress orbit and optic nerves. After the revision surgery the patient's headache and ophthalmoplegia were improved. However, multifocal cerebral infarctions were newly discovered in a postoperative CT scan. We experienced a case of mucormycosis of sphenoid sinus resulting in occlusion of internal carotid artery and multifocal cerebral infarction, and report it with a brief review of these disease entities.

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Management of rhino-orbital mucormycosis

Cited by 19 publications

References 9 publications

Identification of Mucorales isolates from soil using morphological and molecular methods

Identification of Mucorales isolates from soil using morphological and molecular methods

Mycotic Infections of the Eye

A Case Of Cavernous Sinus Syndrome and Mutifocal Cerebral Infarction Related To Mucormycosis Of Sphenoid Sinus

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