Management of residual penile curvature after penile prosthesis placement

Krakhotkin, D.V.; Ralph, David; Blecher, Gideon; Chernylovskyi, Volodymyr A.; Greco, Francesco; Bakurov, Evgeny E; Bugaev, Ruslan A.

doi:10.4103/aja.aja_62_20

Cited by 2 publications

(1 citation statement)

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“…The overall efficiency of both was about 70%, however, these treatments were only used to relieve ED symptoms. The implantation of a penile prosthesis might be the last option, but is highly cost with the risks of infection, erosion and device failure ( 2 ). Recent researches on ED regenerative therapies including gene therapy and stem cell therapy have shown significant benefits in repairing pathological changes of penile tissue of various ED animal models and are important attempts to restore natural erections.…”

Section: Introductionmentioning

confidence: 99%

Deciphering the myth of icariin and synthetic derivatives in improving erectile function from a molecular biology perspective: a narrative review

Niu¹,

Lin²,

Pan³

et al. 2022

Transl Androl Urol

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Background and Objective: Although epimedium herb (EH) has been widely used in ancient Chinese medicine to enhance sexual activity, its pharmacological mechanism is not clear. Modern studies have shown that epimedium herb is rich in icariin (ICA, a flavonoid compound), and 91.2% of icariin is converted to icariside II (ICA II) by hydrolytic enzymes in intestinal bacteria after oral administration. YS-10 is a synthetic derivative of icariside II. The aim of this review was to summarize the contemporary evidence regarding the pharmacokinetics, therapeutic properties, and molecular biological mechanisms of ICA and some ICA derivatives for erectile dysfunction therapy.Methods: A detailed search was conducted in the PubMed database using keywords and phrases, such as "icariin" AND "erectile dysfunction", "icariside II" AND "erectile dysfunction". The publication time is limited to last 20 years. Articles had to be published in peer reviewed journals.Key Content and Findings: ICA and its some derivatives showed the specific inhibition on phosphodiesterase type 5 (PDE5) and the promotion of testosterone synthesis. In addition, by regulating various reliable evidence of signaling pathways such as PI3K/AKT, TGFβ1/Smad2, p38/MAPK, Wnt and secretion of various cytokines, ICA and ICA derivatives can activate endogenous stem cells (ESCs) leading to endothelial cell and smooth muscle cell proliferation, nerve regeneration and fibrosis inhibition, repair pathological changes in penile tissue and improve erectile function.Conclusions: ICA and some of its derivatives could be a potential treatment for restoring spontaneous erections. In addition ICA and his derivatives may also be valuable as a regenerative medicine approach for other diseases, but more clinical and basic researches with high quality and large samples are recommended.

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Section: Introductionmentioning

confidence: 99%