Management of refractory inflammatory bowel disease

Perioperative Anti-Tumor Necrosis Factor Therapy Does Not Increase the Rate of Early Postoperative Complications in Crohn’s Disease

“…1,2 The most common indications for surgical resection are medically refractory disease or medication Presented at SSAT annual meeting at Digestive Disease Week (DDW), 1-5 May 2010 side effects. [1][2][3][4][5][6][7][8] Surgery is also indicated in the treatment of complications of the disease, such as hemorrhage, perforation, obstruction, and fistula formation. Therapy, medical or surgical, rarely results in cure from the disease and the primary objective is to restore the patient to health and well-being.…”

Granulocitoaféresis: viejos procedimientos, nuevas soluciones

“…Sin embargo, la situación actual dista mucho de ser ideal ya que, a pesar de disponer de inmunosupresores no selectivos (5-ASA y esteroides), inmunomoduladores (azatiprina, 6-mercaptopurina y metotrexato) y terapias biológicas (anti-TNFα, anti-integrinas, etc. ), alrededor de un 60% de los pacientes con enfermedad de Crohn (EC) y aproximadamente un 35% de los pacientes con colitis ulcerosa (CU) requieren tratamiento quirúrgico (1,2). Tampoco pueden ignorarse los efectos secundarios de los tratamientos actuales.…”