Management of radiation failure for localized prostate cancer

Jl, Letran; Mk, Brawer

doi:10.1038/sj.pcan.4500225

Cited by 12 publications

(2 citation statements)

References 19 publications

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“…Therefore, focal therapies, such as cryotherapy and high-intensity focused ultrasound, have emerged as feasible less invasive treatments. An accurate tumor localization for the site of local recurrence and distant metastasesis of the utmost importance in order to determine if, and from which, salvage therapy a patient would benefit the most [113][114][115]. Diagnosing disease recurrence is usually performed by measuring serum the PSA level, performing a digital rectal examination and TRUS-guided prostate biopsy, as well as obtaining a bone scan.…”

Section: Local Recurrencementioning

confidence: 99%

Imaging modalities for prostate cancer

Fütterer

Barentsz

Heijmijnk

2009

Expert Review of Anticancer Therapy

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Prostate cancer is the most frequently diagnosed malignancy in the Western male population and the associated socioeconomic impact on healthcare is of great concern. Since the early 1990s, MRI has evolved into an important diagnostic imaging modality for prostate cancer patients. In this review, the applications of diagnostic imaging modalities in prostate cancer, such as transrectal ultrasound, computed tomography and MRI are described. The clinical value of these techniques in prostate cancer detection, localization, characterization, staging and active surveillance are discussed.

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Section: Local Recurrencementioning

confidence: 99%

Imaging modalities for prostate cancer

Fütterer

Barentsz

Heijmijnk

2009

Expert Review of Anticancer Therapy

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“…Some investigators recommend grading of cancer in specimens after radiotherapy, recognizing that the biologic significance of grade may be different from that in untreated cancer [22]. Cheng et al believe that Gleason grade in postirradiation needle biopsy specimens provides useful predictive information and recommend its use in this setting [3] despite suggestions to the contrary [38]. Taken together, the findings suggest that cancer after treatment frequently is related to a process of clonal evolution that results in cancer progression and tumor dedifferentiation.…”

Section: Cancer Grade Stage and Dna Ploidy After Radiotherapymentioning

confidence: 99%

Effect of Radiotherapy on Non-Neoplastic and Malignant Prostate

Iczkowski

2009

TOPATJ

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Pathologists nowadays are frequently confronted with post-radiotherapy biopsies of the prostate. It is critical to recognize the changes of benign prostatic tissue with radiation effect, which include frequent acinar atrophy, acinar distortion, basal cell hyperplasia, decreased acinar/stromal ratio, and stromal fibrosis. The non-neoplastic irradiated prostate can have nuclear enlargement and bizarre nuclei, changes overlapping or exceeding those commonly seen in prostatic adenocarcinoma. The presence of high-grade PIN adjacent to acini in question favors a cancer diagnosis. Ceratin immunostains, particularly cytokeratin 34ßE12, in conjunction with selected other markers, can help the pathologist determine whether residual cancer is present in the most difficult cases.

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Neoplasms of the prostate

Bostwick¹,

Meiers²

2008

Urologic Surgical Pathology

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Management of radiation failure for localized prostate cancer

Cited by 12 publications

References 19 publications

Imaging modalities for prostate cancer

Imaging modalities for prostate cancer

Effect of Radiotherapy on Non-Neoplastic and Malignant Prostate

Neoplasms of the prostate

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