“…The rates of cure in both study groups were comparable with those described previously (3,6,14). An explanation of why mupirocin is more effective than other topical agents in treating impetigo is unclear.…”
Section: Resultssupporting
confidence: 85%
“…One mupirocinresistant isolate was recovered at the end of therapy from a child treated with mupirocin. All (3,6,14). Topical therapy with these agents was clearly less effective than systemic therapy.…”
Section: Resultsmentioning
confidence: 99%
“…It is classically thought to have a streptococcal etiology (3,6,10); however, evidence is accumulating to suggest that the pathophysiology may be changing (2,21). It is now clear that Staphylococcus aureus, along with Streptococcus pyogenes, must be considered a true pathogen in this illness (1).…”
mentioning
confidence: 99%
“…In the past, a number of therapeutic approaches have been used. These have included antiseptic scrubs (19), topical antibiotics (3,7,14), parenteral antibiotics (4,7), and oral antibiotics (3,5,6,11,14,15).…”
“…The rates of cure in both study groups were comparable with those described previously (3,6,14). An explanation of why mupirocin is more effective than other topical agents in treating impetigo is unclear.…”
Section: Resultssupporting
confidence: 85%
“…One mupirocinresistant isolate was recovered at the end of therapy from a child treated with mupirocin. All (3,6,14). Topical therapy with these agents was clearly less effective than systemic therapy.…”
Section: Resultsmentioning
confidence: 99%
“…It is classically thought to have a streptococcal etiology (3,6,10); however, evidence is accumulating to suggest that the pathophysiology may be changing (2,21). It is now clear that Staphylococcus aureus, along with Streptococcus pyogenes, must be considered a true pathogen in this illness (1).…”
mentioning
confidence: 99%
“…In the past, a number of therapeutic approaches have been used. These have included antiseptic scrubs (19), topical antibiotics (3,7,14), parenteral antibiotics (4,7), and oral antibiotics (3,5,6,11,14,15).…”
“…and early 1970s demonstrated the superiority of systemic antibiotics to topical antibiotics for the treatment of impetigo (2)(3)(4)(5)(6)13). Burnett compared oral erythromycin to placebo, wet dressings, and topical neomycin-bacitracin ointment (14,15). Erythromycin had superior therapeutic efficacy in all instances.…”
Section: Studies Performed In the United States In The 1960smentioning
Traditional concepts regarding the bacteriology and therapy of nonbullous impetigo have been reexamined. Although in the United States the disease is considered primarily of streptococcal origin and amenable to penicillin therapy, we found that Staphylococcus aureus was the most common isolate in 71 patients studied. Only two patients yielded pure cultures of group A beta-hemolytic streptococci. All but two isolates of S. aureus were resistant to penicillin; one of these two isolates was also resistant to erythromycin. Erythromycin appeared to be more efficacious than penicillin for the treatment of impetigo.
A trend toward increasing resistance of Staphylococcus aureus to standard antibiotic therapy has been reported. Specimens were taken from 98 patients in our outpatient staff clinic who had clinical signs of superficial skin infections. Patients with erythromycin-resistant S. aureus were contacted by telephone or seen in clinic. The organism was found in 87% of patients. Twenty-two (26%) of the 85 cultures that grew S. aureus were resistant to erythromycin. Treatment failure occurred in one of these patients. We conclude that S. aureus is the most common causative organism in secondary skin infections and impetigo in our patient population. Despite significant erythromycin resistance, there was a low frequency of treatment failure in this group. Erythromycin may still be a reasonable agent in the treatment of uncomplicated superficial skin infections in our community at this time.
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