Management of Pyogenic Cutaneous Infections

Burnett, J W; Med, J

doi:10.1097/00043764-196209000-00018

Cited by 3 publications

(6 citation statements)

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“…The rates of cure in both study groups were comparable with those described previously (3,6,14). An explanation of why mupirocin is more effective than other topical agents in treating impetigo is unclear.…”

Section: Resultssupporting

confidence: 85%

“…One mupirocinresistant isolate was recovered at the end of therapy from a child treated with mupirocin. All (3,6,14). Topical therapy with these agents was clearly less effective than systemic therapy.…”

Section: Resultsmentioning

confidence: 99%

“…It is classically thought to have a streptococcal etiology (3,6,10); however, evidence is accumulating to suggest that the pathophysiology may be changing (2,21). It is now clear that Staphylococcus aureus, along with Streptococcus pyogenes, must be considered a true pathogen in this illness (1).…”

mentioning

confidence: 99%

“…In the past, a number of therapeutic approaches have been used. These have included antiseptic scrubs (19), topical antibiotics (3,7,14), parenteral antibiotics (4,7), and oral antibiotics (3,5,6,11,14,15).…”

mentioning

confidence: 99%

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Randomized clinical trial of topical mupirocin versus oral erythromycin for impetigo

Goldfarb

Crenshaw

O’Horo

et al. 1988

Antimicrob Agents Chemother

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Section: Resultssupporting

confidence: 85%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Randomized clinical trial of topical mupirocin versus oral erythromycin for impetigo

Goldfarb

Crenshaw

O’Horo

et al. 1988

Antimicrob Agents Chemother

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“…and early 1970s demonstrated the superiority of systemic antibiotics to topical antibiotics for the treatment of impetigo (2)(3)(4)(5)(6)13). Burnett compared oral erythromycin to placebo, wet dressings, and topical neomycin-bacitracin ointment (14,15). Erythromycin had superior therapeutic efficacy in all instances.…”

Section: Studies Performed In the United States In The 1960smentioning

confidence: 99%

Impetigo: A Reassessment of Etiology and Therapy

Barton

Friedman

1987

Pediatric Dermatology

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Traditional concepts regarding the bacteriology and therapy of nonbullous impetigo have been reexamined. Although in the United States the disease is considered primarily of streptococcal origin and amenable to penicillin therapy, we found that Staphylococcus aureus was the most common isolate in 71 patients studied. Only two patients yielded pure cultures of group A beta-hemolytic streptococci. All but two isolates of S. aureus were resistant to penicillin; one of these two isolates was also resistant to erythromycin. Erythromycin appeared to be more efficacious than penicillin for the treatment of impetigo.

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The Frequency of Erythromycin‐Resistant Staphylococcus aureus in Impetiginized Dermatoses

Misko

Terracina

Diven

1995

Pediatric Dermatology

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A trend toward increasing resistance of Staphylococcus aureus to standard antibiotic therapy has been reported. Specimens were taken from 98 patients in our outpatient staff clinic who had clinical signs of superficial skin infections. Patients with erythromycin-resistant S. aureus were contacted by telephone or seen in clinic. The organism was found in 87% of patients. Twenty-two (26%) of the 85 cultures that grew S. aureus were resistant to erythromycin. Treatment failure occurred in one of these patients. We conclude that S. aureus is the most common causative organism in secondary skin infections and impetigo in our patient population. Despite significant erythromycin resistance, there was a low frequency of treatment failure in this group. Erythromycin may still be a reasonable agent in the treatment of uncomplicated superficial skin infections in our community at this time.

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Management of Pyogenic Cutaneous Infections

Cited by 3 publications

References 0 publications

Randomized clinical trial of topical mupirocin versus oral erythromycin for impetigo

Randomized clinical trial of topical mupirocin versus oral erythromycin for impetigo

Impetigo: A Reassessment of Etiology and Therapy

The Frequency of Erythromycin‐Resistant Staphylococcus aureus in Impetiginized Dermatoses

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