Management of purpura fulminans skin lesions in a premature neonate with sepsis: a case study

Abstract

Purpura fulminans is a severe and rapidly progressive septic process characterised by the development of haemorrhagic and ecchymotic lesions and skin necrosis. It can appear on any part of the body but predominantly affects the limbs. Purpura fulminans is a rare but possible complication in paediatric patients, especially neonates. It can increase their risk of morbidity and mortality if not treated early and cause a severe long-term condition in survivors of the infectious episode, including amputation. For professionals involved in wound healing, purpura fulminans poses a major challenge. This report describes the case of a premature neonate with extensive purpura fulminans of the legs and arms. Topical treatment of the limbs and purpuric areas with hyperoxygenated fatty acids (HOFAs) every two hours produced an improvement in the lesions. Complete healing was achieved using moist wound healing products. Early topical application of HOFAs appears to be a safe treatment that improves tissue microcirculation in paediatric patients with Purpura fulminans, minimising sepsis-related skin damage.

Diagnostic and prognostic value of PCT and RDW in premature infants with septicemia

“…If the measurement data in the study conforms to the normal distribution, it is presented in the form of mean ± standard deviation false(truex−thinmathspace±s), and the falset test is used for inter group comparison. [14] If not, it uses falseM(P25∼P75) for representation and Mann Whitney U test for Mann–Whitney U testthe 2 groups; Friedman test is used for skewed distribution data related to multiple groups; Pairwise comparison uses Wilcoxon signed rank sum test. [15] The counting data is expressed in frequency or percentage form, and falseχ2 test is utilized for inter group comparison.…”

Purpura Fulminans in an Asplenic Intravenous Drug User

“…33,34 Hyperoxygenated fatty acids have been noted to aid in more rapid wound healing in infants with PF. 35 Fresh frozen plasma is one method to replace missing factors, but it contains little protein C. 36 Outcomes with recombinant human activated protein C (drotrecogin alfa) are mixed, and studies have shown no benefit in reducing the risk for death. 37,38 Protein C concentrate has shown therapeutic benefit in some case reports and small retrospective studies.…”

Comparative evaluation of the effect of aloe vera gel, olive oil, and compound aloe vera gel-olive oil on prevention of pressure ulcer: A randomized controlled trial

“…One of the alternatives to these compounds is olive oil which is more accessible and more affordable than HOFA. [ 12 18 ] Olive oil is one of the medicinal plants that, due to its uncomplicated and many healing properties, has attracted the attention of many researchers. [ 8 11 ] Olive oil is rich in essential fatty acids oleic acid, linoleic acid, phytosterol, and squalene, which increase hydration, skin protection, and skin regeneration.…”