Management of Pseudomonas aeruginosa Infection After Lung Transplantation Across the UK and the Impact on Long-Term Survival

Gan, T.C.; Cockburn, Alison; Yung, Henry; Karimi, Ebrahim; Dirmantaite, Laura; Khan, Mohammad Shamim; Perry, Audrey; Gell, R.; Al-Aloul, M.; Thompson, Richard; Parmar, Jasvir; Carby, Martin; Fisher, Andrew J.

doi:10.1016/j.healun.2017.01.1537

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“…Patients with CF are most at risk of developing infection from pathogens that inhabit their upper respiratory tract [ 26 , 27 , 28 ]. In the analysis of Gan et al, persistent infection was found in the post-transplant period in 60% (134 out of 224) of recipients with CF and in 6% (38 out of 612) of patients with another disease [ 29 ]. In the presented study, of 32 recipients with the presence of purulent discharge, nine suffered from CF.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Donor to Recipient Pathogen Transmission in Relation to Cold Ischemic Time and Other Selected Aspects of Lung Transplantation—Single Center Experience

et al. 2023

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Background: Infections are one of the leading causes of death in the early postoperative period after lung transplantation (LuTx). Methods: We analyzed 59 transplantations and culture results of the donor bronchial aspirates (DBA), graft endobronchial swabs (GES), and recipient cultures (RC) before and after the procedure (RBA). We correlated the results with a cold ischemic time (CIT), recipient intubation time, and length of stay in the hospital and intensive care unit (ICU), among others. Results: CIT of the first and second lungs were 403 and 541 min, respectively. Forty-two and eighty-three percent of cultures were positive in DBA and GES, respectively. Furthermore, positive results were obtained in 79.7% of RC and in 33.9% of RBA. Longer donor hospitalization was correlated with Gram-negative bacteria isolation in DBA. Longer CIT was associated with Gram-positive bacteria other than Staphylococcus aureus in GES and it resulted in longer recipient stay in the ICU. Furthermore, longer CIT resulted in the development of the new pathogens in RBA. Conclusion: Results of GES brought more clinically relevant information than DBA. Donor hospitalization was associated with the occurrence of Gram-negative bacteria. Positive cultures of DBA, GES, and RBA were not associated with recipient death.

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