Management of Prostate Cancer in China: A Multicenter Report of 6 Institutions

Peyromaure, Michaël; Debré, B; Mao, Kaili; Zhang, Guoqiang; Wang, Yiran; Sun, Zhongquan; Xu, Danfeng; Jiang, Jun; Sun, Yinghao

doi:10.1097/01.ju.0000176817.46279.93

Cited by 51 publications

(51 citation statements)

References 9 publications

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“…In a retrospective analysis of 431 consecutive Chinese patients treated for PCa, PCa was suspected because of increased PSA in only 6.2% of cases. Moreover, only 26% of patients had normal DRE [2]. These results differ markedly from those in Western reports.…”

Section: Discussioncontrasting

confidence: 88%

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Laparoscopic radical prostatectomy: oncological and functional results of 126 patients with a minimum 3-year follow-up at a single Chinese institute

Gao¹,

Zhou²,

Li³

et al. 2009

Asian J Androl

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In this study we evaluate the oncological and functional results of the largest cohort of patients in China treated by laparoscopic radical prostatectomy (LRP) and with at least 3 years of follow-up. 126 inconsecutive patients (range 56-78 years, median 62.5) who had an LRP were retrospectively analyzed. The mean prostate specific antigen level and Gleason score was 13.4 ng mL -1 and 6.4, respectively. Twenty-seven patients had unilateral or bilateral nerve preservation and 29 had pelvic lymphadenectomy. Multivariate analysis was used to adjust for differences in clinical and pathological features when comparing the risk for biochemical progression-free survival (bPFS). Urinary continence was assessed by incontinence questionnaire and erectile function by the Sexual Health Inventory for Men score. The mean operative duration was 250 min and blood loss 354 mL. Five patients received blood transfusion and nine had complications, including rectal injury (two), ureteral injury (one), active bleeding (one), bladder neck stenosis (two), paralytic ileus (one), subcutaneous hematoma (one) and port-site hernia (one). The overall positive surgical margin rate was 20.6% and correlated with pathological stage and Gleason score respectively (P = 0.03, P < 0.001 respectively). All patients had ≥ 3 years of follow-up (range 3-6.75 years, mean 4.6, median 4.75). At 3 years of follow-up, the overall survival rate was 100% and the bPFS was 81.0% in all patients; 124 patients (98.4%) were continent; 22 of 27 patients (81.5%) who underwent nerve preservation retained erectile function. Our series confirms that LRP is an effective, safe and precise technique at Chinese institution.

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Section: Discussioncontrasting

confidence: 88%

“…Although PCa is uncommon in China, some recent reports indicate that its incidence is increasing rapidly [2]. Gu [3] evaluated the incidence of PCa at 187 hospitals based in 26 Chinese provinces.…”

Section: Introductionmentioning

confidence: 99%

Laparoscopic radical prostatectomy: oncological and functional results of 126 patients with a minimum 3-year follow-up at a single Chinese institute

Gao¹,

Zhou²,

Li³

et al. 2009

Asian J Androl

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“…In China, screening for prostate cancer using digital rectal examination and PSA is not routinely conducted in practice. Most newly diagnosed patients with prostate cancer are symptomatic and high-risk (42). In our opinion, the lack of several rounds of screening during the last 15 to 20 years might determine the different characteristics of our population.…”

Section: Discussionmentioning

confidence: 98%

ERG Rearrangement for Predicting Subsequent Cancer Diagnosis in High-Grade Prostatic Intraepithelial Neoplasia and Lymph Node Metastasis

Gao

Zhou

et al. 2012

Clinical Cancer Research

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Purpose: We aimed to analyze whether ERG rearrangement in biopsies could be used to assess subsequent cancer diagnosis in high-grade prostatic intraepithelial neoplasia (HGPIN) and the risk of lymph node metastasis in early prostate cancer.Experimental Design: Samples from 523 patients (361 with early prostate cancer and 162 with HGPIN) were collected prospectively. On the basis of the cutoff value established previously, the 162 patients with HGPIN were stratified to two groups: one with an ERG rearrangements rate !1.6% (n ¼ 59) and the other with an ERG rearrangements rate <1.6% (n ¼ 103). For the 361 prostate cancer cases undergoing radical prostatectomy, 143 had pelvic lymph node dissection (node-positive, n ¼ 56 and node-negative, n ¼ 87). All ERG rearrangement FISH data were validated with ERG immunohistochemistry.Results: A total of 56 (of 59, 94.9%) HGPIN cases with an ERG rearrangements rate !1.6% and 5 (of 103, 4.9%) HGPIN cases with an ERG rearrangements rate <1.6% were diagnosed with prostate cancer during repeat biopsy follow-ups (P < 0.001). There were significant differences in ERG rearrangement rates between lymph node-positive and -negative prostate cancer (P < 0.001). The optimal cutoff value to predict lymph node metastasis by ERG rearrangement was established, being 2.6% with a sensitivity at 80.4% [95% confidence interval (CI), 67.6-89.8] and a specificity at 85.1% (95% CI, 75.8-91.8). ERG protein expression by immunohistochemistry was highly concordant with ERG rearrangement by FISH.Conclusions: The presence of ERG rearrangement in HGPIN lesions detected on initial biopsy warrants repeat biopsies and measuring ERG rearrangement could be used for assessing the risk of lymph node metastasis in early prostate cancer. Clin Cancer Res; 18(15); 4163-72. Ó2012 AACR.

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“…Peyromaure et al [6] found that the majority of PC cases in China were diagnosed after urinary symptoms (75.9%) or bone pain (12.8%). PC was suspected because of increased PSA in only 6.2% of cases.…”

Section: Introductionmentioning

confidence: 99%

Age-specific PSA reference ranges in Chinese men without prostate cancer

Liu¹,

Sun²,

Xu³

et al. 2008

Asian J Androl

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This study is to determine age-specific prostate-specific antigen (PSA) distributions in Chinese men without prostate cancer (PC) and to recommend reference ranges for this population after comparison with other studies. From September 2003 to December 2006, 9 374 adult men aged from 18 to 96 years agreed to participate in the study. After all cases of PC were excluded, 8 422 adult men participated in statistical analysis and were divided into five age groups. Simple descriptive statistical analyses were carried out and quartiles and 95th percentiles were calculated for each age group. The age-specific PSA reference ranges are as follows: 40-49 years, 2.15 ng mL -1 ; 50-59 years, 3.20 ng mL -1 ; 60-69 years, 4.10 ng mL -1 ; 70-79 years, 5.37 ng mL -1 . The results indicate that the ethnic differences in PSA levels are obvious. The currently adopted Oesterling's age-specific PSA reference ranges are not appropriate for Chinese men. The reference ranges of this study should be more suitable to Chinese men.

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Management of Prostate Cancer in China: A Multicenter Report of 6 Institutions

Abstract: The management of PCa in China differs from that in Western countries. To date surgical castration represents standard treatment. Screening detection of PCa could help detect earlier stage tumors and improve the outcome in patients.

Cited by 51 publications

References 9 publications

Laparoscopic radical prostatectomy: oncological and functional results of 126 patients with a minimum 3-year follow-up at a single Chinese institute

Laparoscopic radical prostatectomy: oncological and functional results of 126 patients with a minimum 3-year follow-up at a single Chinese institute

ERG Rearrangement for Predicting Subsequent Cancer Diagnosis in High-Grade Prostatic Intraepithelial Neoplasia and Lymph Node Metastasis

Age-specific PSA reference ranges in Chinese men without prostate cancer

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