Management of Primary Necrotizing Fasciitis of the Breast: A Systematic Review

Abstract

Purpose: Necrotizing fasciitis (NF) is a life-threatening infection that involves spreading necrosis of the subcutaneous tissue and fascia that affects the extremities, abdominal wall, and perineum. Primary infection of the breast is a rare occurrence. Shah et al described the first case of primary breast NF and recommended radical “pseudotumor” excision and delayed skin closure months after resolution. Numerous other cases reported were successfully managed with different strategies. We aimed to summarize management options for primary breast NF through a systematic review of the literature. Methods: A systematic review of English literature was performed using PubMed. A total of 58 abstracts were reviewed. Data were abstracted from 25 cases that met inclusion criteria. Results: A total of 25 cases of primary NF of the breast without an inciting event were found within the literature. Common initial operations included total mastectomy (36.0%), excisional debridement (32.0%), and partial mastectomy (12.0%). A total or radical mastectomy was completed for definitive source control in 13 (52.0%) cases. A total of 18 cases underwent reconstruction. Split-thickness skin grafts (44.4%) and delayed primary closures (33.3%) were the most common methods of reconstruction. Conclusion: Majority of cases with primary breast NF are managed with a total mastectomy to gain source control. Reconstruction using split-thickness skin grafts was most common. Other options included delayed primary closure, full thickness skin grafts, local tissue rearrangement, and pedicle flap reconstruction. Reconstruction should be patient dependent, but the whole arsenal of the reconstructive ladder may be used.

Breast rescue after necrotizing fasciitis

“…Treatment is mainly surgical and consisting of early debridement and radical excision of the infected tissue [ 11 ]. Through a review of literature, Marongiu found that mastectomy has been reported to be the most common surgical procedure [ 4 ].…”

Colonization of breast tissue by Moraxella Catarrhalis associated with necrotizing fasciitis. A case report.

“…There are a wide variety of reconstruction options with split-thickness skin grafts being a common choice. Reconstruction of the defect can be completed within 2 weeks or once the patient is stable and free of infection 11 . Partial thickness skin grafts are indicated for large wounds and can survive in places with little vascularity such as breast tissue 12 .…”

Necrotizing Fasciitis of the Breast Requiring a Life-Saving Mastectomy: A Case Report and Literature Review

“…Split-thickness skin grafts (44.4%) and delayed primary closures (33.3%) were the most common methods of reconstruction. Septic shock at presentation was an independent risk factor for mortality (12.5%) in these patients (p<0.001) [ 35 , 36 ].…”