Management of primary megaureter in infancy

Cozzi, Francesco; Madonna, L.; Maggi, E.; Piacenti, S.; Bonanni, M.; Roggini, Mario; Capocaccia, P; Pachı́, A.

doi:10.1016/0022-3468(93)90511-i

Cited by 24 publications

(14 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, it was revealed that the UNC patients had a more distinct dilatation of the ureter initially than the ''non-UNC'' group. For group 1 we determined 9 ± 3 mm (4-34) proximally and 7±3 mm (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) distally. The maximum pre-operative diameter of the 16 neoimplanted ureters later was 15 ± 3 mm (6-25) proximally and 15 ± 5 mm (6-23) distally.…”

Section: Resultsmentioning

confidence: 99%

“…A spontaneous improvement rate of 43% to 100 % (median 90) of the unoperated patients was registered. In studies which refer exclusively to asymptomatic pre-and/ or directly post-natally diagnosed megaureters, the rate of the children operated on is only between 0 and 28% [3,8,[19][20][21]. A long-time follow-up revealed that the performance of the kidneys with a primary megaureter produced the expected growth during the organ maturation in case of conservative treatment [5].…”

Section: Discussionmentioning

confidence: 98%

“…The hypothesis was put forward that the primary megaureter of the fetuses and the neonates constitutes a separate entity compared to the primary obstructive megaureter of the elder child [1,2]. The original operative treatment concept has now been replaced by a conservative treatment approach mainly [1,[3][4][5][6][7][8]. However, the differentiation between a non-relevant dilatation of the urinary tract (non-obstructive, non-reflux megaureter) and a relevant obstruction jeopardizing the renal function (obstructive megaureter) is important [2].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Renal Function and Urine Drainage after Conservative or Operative Treatment of Primary (Obstructive) Megaureter in Infants and Children

et al. 2006

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Renal Function and Urine Drainage after Conservative or Operative Treatment of Primary (Obstructive) Megaureter in Infants and Children

et al. 2006

View full text Add to dashboard Cite

show abstract

“…The mean age at surgery was than half of cases [1][2][3][4][5]; these reports indicate a possible segmental maturational delay of the ureteric lower tract 2.11 years (range 6 months-8 years). Using 99mTc-labelled DTPA diuresis renography, obstruction was con- [3,6].…”

Section: Methodsmentioning

confidence: 99%

Segmental up‐regulation of transforming growth factor‐β in the pathogenesis of primary megaureter. An immunocytochemical study

Nicòtina

Romeo

Arena³

et al. 1997

British Journal of Urology

View full text Add to dashboard Cite

Objective To examine the maturational-delay hypothesis were like the fetal ureteric buds at 26-38 weeks of gestation. Positive TGF-b immunoreactions were of primary megaureter (PM), i.e. that the condition arises by a segmental maturational delay of the uretdetected in the longitudinal muscle layer in the ureter from patients 6-12 months old. Such reactions weakeric wall that can resolve spontaneously within the first year of life, using comparative immunocytochemened progressively in those patients older than 1 year, becoming negative in all children older than 3 years. istry of ureters resected from infants and from homologous pre-natal ureters.The TGF-b immunolabelling in resected ureters was closely similar to that in fetal ureters from 20 to Materials and methods Seventeen distal urinary tracts were obtained from children with PM who were 26-week old calves. Conclusions From these results, PM should be ascribed referred for surgery (aged 6 months to 8 years, mean 2.1 years). These were compared with ureteric buds to a segmental developmental delay of the terminal ureter arising at about 20 weeks of gestation, with a obtained from 11-week-old human and 11-to 38-week-old calf fetuses. The samples were immunospossible pathogenetic involvement of autocrine TGF-b overexpression. tained using a monoclonal antibody specific for transforming growth factor b (TGF-b).

show abstract

“…Spontaneous resolution usually occurs during the first year of life 41 . Asymptomatic infants with good differential renal function (good function in each of the two kidneys) on DTPA renography can be managed conservatively regardless of their postfurosemide drainage curve with spontaneous improvement in almost all 42 . Serial ultrasound examinations may also be necessary for follow‐up of children with UV‐J obstruction.…”

Section: Diagnosis Of Cakutmentioning

confidence: 99%

Medical management of congenital anomalies of the kidney and urinary tract

Hiraoka

2003

Pediatrics International

View full text Add to dashboard Cite

Renal damage in children has been found to be more congenital in origin than was previously thought. Congenital anomalies of the kidney and urinary tract (CAKUT) involve renal dysplasia, renal hypoplasia, urinary tract obstruction and vesicoureteral reflux. CAKUT are sometimes bilateral and different types often coexist. Depending on their types and severity, children with CAKUT often have varying degrees of a reduced number of nephrons at birth. CAKUTare now the leading cause of renal failure in children. Children with renal dysplasia or obstructive uropathy may have abnormal renal tubules, and tend to lose essential water and sodium in urine. This can lead to poor body growth unless they are supplemented with water and sodium. Children with severe ureteric reflux often develop urinary infection and renal scarring. Renal scarring can further increase the risk of renal failure in children who already have other CAKUTand fewer nephrons than normal. Hypertension and proteinuria may develop in children with renal dysplasia and further aggravate renal function unless they are treated. Recent advances in the understanding and management of CAKUT make it possible for children with CAKUT to grow normally, have fewer complications such as urinary infection, have longer renal survival, and survive even with end-stage renal diseases through renal replacement therapy.

show abstract

Management of primary megaureter in infancy

Cited by 24 publications

References 6 publications

Renal Function and Urine Drainage after Conservative or Operative Treatment of Primary (Obstructive) Megaureter in Infants and Children

Renal Function and Urine Drainage after Conservative or Operative Treatment of Primary (Obstructive) Megaureter in Infants and Children

Segmental up‐regulation of transforming growth factor‐β in the pathogenesis of primary megaureter. An immunocytochemical study

Medical management of congenital anomalies of the kidney and urinary tract

Contact Info

Product

Resources

About